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1. WO2020117736 - HYDROXYPROPYL METHYLCELLULOSE ACETATE SUCCINATES OF VERY HIGH MOLECULAR WEIGHT

Publication Number WO/2020/117736
Publication Date 11.06.2020
International Application No. PCT/US2019/064134
International Filing Date 03.12.2019
IPC
C08B 13/00 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
BPOLYSACCHARIDES; DERIVATIVES THEREOF
13Preparation of cellulose ether-esters
A61K 47/38 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
38Cellulose; Derivatives thereof
CPC
A61K 47/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
38Cellulose; Derivatives thereof
A61K 9/0056
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
A61K 9/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor; ; Other semi-solid forms, e.g. creams, sticks, gels
C08B 13/00
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
BPOLYSACCHARIDES; DERIVATIVES THEREOF
13Preparation of cellulose ether-esters
Applicants
  • DDP SPECIALTY ELECTRONIC MATERIALS US, INC. [US]/[US]
Inventors
  • PETERMANN, Oliver O.
Agents
  • ZHENG, Hanxing
Priority Data
18210002.404.12.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HYDROXYPROPYL METHYLCELLULOSE ACETATE SUCCINATES OF VERY HIGH MOLECULAR WEIGHT
(FR) ACÉTATE-SUCCINATES D'HYDROXYPROPYLMÉTHYLCELLULOSE DE MASSE MOLÉCULAIRE TRÈS ÉLEVÉE
Abstract
(EN)
A hydroxypropyl methylcellulose acetate succinate having a weight average molecular weight Mw of at least 800,000 Dalton is useful for preparing solid dispersions, coated dosage forms, capsule shells and hydrogels. The hydrogel is formed from the hydroxypropyl methylcellulose acetate succinate and water by heat treatment and syneresis, wherein the hydrogel, at a temperature of 21°C, has a water content of from 15 to 97 weight percent, based on the total weight of the hydrogel.
(FR)
La présente invention concerne un acétate-succinate d'hydroxypropylméthylcellulose ayant une masse moléculaire moyenne en poids Mw d'au moins 800 000 daltons qui est utile pour préparer des dispersions solides, des formes posologiques enrobées, des enveloppes de capsules et des hydrogels. L'hydrogel est formé à partir de l'acétate-succinate d'hydroxypropylméthylcellulose et de l'eau par traitement thermique et synérèse, l'hydrogel, à une température de 21 °C, ayant une teneur en eau de 15 à 97 pour cent en poids, par rapport au poids total de l'hydrogel.
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