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1. WO2020117646 - REDUCTION OF HYPERGLYCEMIA BY ADMINISTRATION OF DIMETHYLFORMAMIDE FOR TREATING HYPERGLYCEMIC CONDITIONS, INCLUDING DIABETES MELLITUS

Publication Number WO/2020/117646
Publication Date 11.06.2020
International Application No. PCT/US2019/063946
International Filing Date 02.12.2019
IPC
G01N 27/12 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
02by investigating impedance
04by investigating resistance
12of a solid body in dependence upon absorption of a fluid; of a solid body in dependence upon reaction with a fluid
G01N 27/414 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
403Cells and electrode assemblies
414Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
G01N 33/543 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
CPC
A61K 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
A61K 9/0053
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
A61K 9/0095
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0087Galenical forms not covered by A61K9/02 - A61K9/7023
0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
Applicants
  • KROSS, Robert, D. [US]/[US]
  • VILLANUEVA LOPEZ, Guadalupe, Cleva [MX]/[MX]
Inventors
  • KROSS, Robert, D.
  • VILLANUEVA LOPEZ, Guadalupe, Cleva
Agents
  • SCHINDLER, Edwin, D.
Priority Data
16/699,67401.12.2019US
62/917,29103.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) REDUCTION OF HYPERGLYCEMIA BY ADMINISTRATION OF DIMETHYLFORMAMIDE FOR TREATING HYPERGLYCEMIC CONDITIONS, INCLUDING DIABETES MELLITUS
(FR) RÉDUCTION DE L'HYPERGLYCÉMIE PAR ADMINISTRATION DE DIMÉTHYLFORMAMIDE POUR TRAITER DES ÉTATS HYPERGLYCÉMIQUES, Y COMPRIS LE DIABÈTE SUCRÉ
Abstract
(EN)
A treatment for a hyperglycemic condition, including diabetes mellitus, includes the step of administering to a human being dimethylformamide ("DMF"), which has the chemical structural formula (I). DMF can be administered to the human patient in a wide variety of ways, however it is preferable that the administration of DMF be performed orally and the dose of DMF could be combined with numerous inert substances known to the prior art, such as a sugarless fruit juice concentrate. The preferred daily dosage of DMF administered to a person would be about 0.041 mg/kg body weight to about 1.23 mg/kg of body weight of the person.
(FR)
La présente invention concerne un traitement pour un état hyperglycémique, comprenant le diabète sucré, qui comprend l'étape consistant à administrer à un être humain du diméthylformamide ("DMF"), qui a la formule structurale chimique (I). Le DMF peut être administré au patient humain d'une grande variété de manières mais il est préférable que l'administration de DMF soit effectuée par voie orale, et la dose de DMF doit pouvoir être combinée à de nombreuses substances inertes connues de l'état de la technique, telles qu'un concentré de jus de fruit sans sucre. Le dosage quotidien préféré de DMF administré à un individu est d'environ 0,041 mg/kg de poids corporel à environ 1,23 mg/kg de poids corporel de l'individu.
Also published as
Latest bibliographic data on file with the International Bureau