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1. WO2020117637 - PRODRUGS OF QUINUCLIDINE RING-CONTAINING MUSCARINIC AGONISTS AND COMPOSITIONS AND METHODS THEREOF

Publication Number WO/2020/117637
Publication Date 11.06.2020
International Application No. PCT/US2019/063923
International Filing Date 02.12.2019
IPC
C07D 453/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
453Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02containing not further condensed quinuclidine ring systems
A61K 31/439 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
439the ring forming part of a bridged ring system, e.g. quinuclidine
CPC
A61K 47/40
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
40Cyclodextrins; Derivatives thereof
C07D 453/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
453Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02containing not further condensed quinuclidine ring systems
C07F 9/59
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
553having one nitrogen atom as the only ring hetero atom
576Six-membered rings
59Hydrogenated pyridine rings
Applicants
  • PRESBYOPIA THERAPIES LLC [US]/[US]
Inventors
  • HORN, Gerald
Agents
  • RAINCROW, Jeremy D.
  • GEIMER, Stephen, D.
  • MCLAUGHLIN, F., William
  • KATZ, Martin, L.
  • CLARK, Jeffrey, L.
Priority Data
62/775,42505.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PRODRUGS OF QUINUCLIDINE RING-CONTAINING MUSCARINIC AGONISTS AND COMPOSITIONS AND METHODS THEREOF
(FR) PROMÉDICAMENTS AGONISTES MUSCARINIQUES CONTENANT UN CYCLE QUINUCLIDINE ET COMPOSITIONS ET MÉTHODES ASSOCIÉES
Abstract
(EN)
The present invention is directed to derivatives and prodrugs of quinuclidine-ring containing compounds. The present invention is further directed to ophthalmo!ogical compositions comprising a therapeutically effective amount of a compound of the present invention and one or more pharmaceutically acceptable excipients. The present invention is further directed to a methods of treating presbyopia or glaucoma or reducing hyperemia comprising administering to a patient in need thereof a therapeutically effective amount of a compound of the present invention.
(FR)
La présente invention concerne des dérivés et des promédicaments de composés contenant un cycle quinuclidine. La présente invention concerne en outre des compositions ophtalmiques comprenant une quantité thérapeutiquement efficace d'un composé de la présente invention et un ou plusieurs excipients pharmaceutiquement acceptables. La présente invention concerne en outre des procédés de traitement de la presbytie ou du glaucome ou de réduction de l'hyperémie, comprenant l'administration à un patient qui en a besoin d'une quantité thérapeutiquement efficace d'un composé de la présente invention.
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