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1. WO2020117626 - 4-AMINO OR 4-ALKOXY-SUBSTITUTED ARYL SULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS

Publication Number WO/2020/117626
Publication Date 11.06.2020
International Application No. PCT/US2019/063909
International Filing Date 02.12.2019
IPC
C07D 495/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C12Q 1/26 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
26involving oxidoreductase
Applicants
  • MERCK SHARP & DOHME CORP. [US]/[US]
  • BUNGARD, Christopher J. [US]/[US] (US)
  • CHEN, Helen Y. [US]/[US] (US)
  • COX, Jason M. [US]/[US] (US)
  • GUO, Liangqin [US]/[US] (US)
  • KELLY, Michael J. III [US]/[US] (US)
  • KIM, Ronald M. [US]/[US] (US)
  • LAYTON, Mark E. [US]/[US] (US)
  • LIU, Hong [US]/[US] (US)
  • LIU, Jian [US]/[US] (US)
  • PATEL, Mehul F. [US]/[US] (US)
  • PERKINS, James J. [US]/[US] (US)
  • WANG, Deping [US]/[US] (US)
  • WON, Walter [US]/[US] (US)
  • YU, Younong [US]/[US] (US)
  • ZHANG, Ting [CN]/[US] (US)
Inventors
  • BUNGARD, Christopher J.
  • CHEN, Helen Y.
  • COX, Jason M.
  • GUO, Liangqin
  • KELLY, Michael J. III
  • KIM, Ronald M.
  • LAYTON, Mark E.
  • LIU, Hong
  • LIU, Jian
  • PATEL, Mehul F.
  • PERKINS, James J.
  • WANG, Deping
  • WON, Walter
  • YU, Younong
  • ZHANG, Ting
Common Representative
  • MERCK SHARP & DOHME CORP.
Priority Data
62/775,68105.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 4-AMINO OR 4-ALKOXY-SUBSTITUTED ARYL SULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS
(FR) COMPOSÉS D'ARYLE SULFONAMIDE SUBSTITUÉS PAR 4-AMINO OU 4-ALCOXY AYANT UNE ACTIVITÉ SÉLECTIVE DANS DES CANAUX SODIQUES SENSIBLES À LA TENSION
Abstract
(EN)
Disclosed are compounds of Formula (I), Formula (II), or a salt thereof: Formula (I) Formula (II) which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (I), Formula (II) or their salts, and methods of treating pain disorders, cough, and itch using the same.
(FR)
L'invention concerne des composés de formule (I), de formule (II), ou un sel de ceux-ci : formule (I) formule (II), dans lesquelles les composés ont des propriétés d'inhibition des canaux ioniques Nav 1.7 présents dans les neurones périphériques et sympathiques. La présente invention concerne également des formulations pharmaceutiques comprenant les composés de formule (I), formule (II) ou des sels de ceux-ci, et des méthodes de traitement de troubles de la douleur, de la toux et de démangeaisons les utilisant.
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