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1. WO2020117625 - CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS

Publication Number WO/2020/117625
Publication Date 11.06.2020
International Application No. PCT/US2019/063908
International Filing Date 02.12.2019
IPC
C07H 19/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
14Pyrrolo-pyrimidine radicals
C07H 19/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
16Purine radicals
C07H 19/23 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
23Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14-C07H19/22222
Applicants
  • MERCK SHARP & DOHME CORP. [US]/[US]
  • ALTMAN, Michael, D. [US]/[US] (US)
  • CHANG, Wonsuk [US]/[US] (US)
  • CUMMING, Jared, N. [US]/[US] (US)
  • LIU, Hong [US]/[US] (US)
  • TROTTER, Benjamin Wesley [US]/[US] (US)
Inventors
  • ALTMAN, Michael, D.
  • CHANG, Wonsuk
  • CUMMING, Jared, N.
  • LIU, Hong
  • TROTTER, Benjamin Wesley
Common Representative
  • MERCK SHARP & DOHME CORP.
Priority Data
62/776,71707.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
(FR) COMPOSÉS DI-NUCLÉOTIDIQUES CYCLIQUES UTILISÉS EN TANT QU'AGONISTES DE STING
Abstract
(EN)
A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2a, R3, R3a, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds. (I)
(FR)
La présente invention concerne une classe de composés polycycliques de formule générale (I), dans laquelle Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2a, R3, R3a, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a et R9 sont tels que définis dans la description, qui peuvent être utiles en tant qu'inducteurs de la production d'interféron de type I, en particulier en tant qu'agents actifs de STING. L'invention concerne également des procédés pour la synthèse et l'utilisation des composés. (I)
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