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1. WO2020117610 - APPARATUS FOR MANUFACTURING CELL THERAPY PRODUCT

Publication Number WO/2020/117610
Publication Date 11.06.2020
International Application No. PCT/US2019/063822
International Filing Date 28.11.2019
IPC
B01F 7/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
7Mixers with rotary stirring devices in fixed receptacles; Kneaders
B01F 7/16 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
7Mixers with rotary stirring devices in fixed receptacles; Kneaders
16with stirrers rotating about a vertical axis
B01F 9/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
9Mixers with rotating receptacles
B01L 1/02 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
1Enclosures; Chambers
02Air-pressure chambers; Air-locks therefor
C12M 1/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
C12M 1/26 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
26Inoculator or sampler
CPC
B01F 7/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
7Mixers with rotary stirring devices in fixed receptacles ; , i.e. movement of the receptacle not being meant to effect the mixing
B01F 7/16
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
7Mixers with rotary stirring devices in fixed receptacles ; , i.e. movement of the receptacle not being meant to effect the mixing
16with stirrers rotating about a substantially vertical axis
B01F 9/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
9Mixers with rotating receptacles, ; i.e. the rotary motion is imparted to effect the mixing
B01L 1/02
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
1Enclosures; Chambers
02Air-pressure chambers; Air-locks therefor
Applicants
  • WEI, Min [US]/[US]
Inventors
  • WEI, Min
Priority Data
62/777,11208.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) APPARATUS FOR MANUFACTURING CELL THERAPY PRODUCT
(FR) APPAREIL DE FABRICATION DE PRODUIT DE THÉRAPIE CELLULAIRE
Abstract
(EN)
A system and the method of use for processing a cell therapy product includes a centrifugation container and a rotor generating centrifugal field that extends to the centrifugation container. The centrifugation container has a substantially cylindrically shaped container body and a movable plunger rod. The container body contains cell suspension and the movable plunger rod is configured to have a mixing blade at the end of the movable plunger rod contacting the cell suspension in the container body. The mixing blade on the movable plunger rod generates mixing force applied to the cell suspension when the movable plunger rod is rotated around axis of the container body. The end of the movable plunger rod contacting the cell suspension is also movable in the container body along longitudinal direction of the container body when withdrawing and expelling fluid in and out of the centrifugation container body.
(FR)
Un système et le procédé d'utilisation pour traiter un produit de thérapie cellulaire comprennent un récipient de centrifugation et un rotor générant un champ centrifuge qui s'étend vers le récipient de centrifugation. Le récipient de centrifugation a un corps de récipient de forme sensiblement cylindrique et une tige de piston mobile. Le corps de récipient contient une suspension de cellule et la tige de piston mobile est configurée pour avoir une lame de mélange à l'extrémité de la tige de piston mobile en contact avec la suspension de cellule dans le corps de récipient. La lame de mélange sur la tige de piston mobile génère une force de mélange appliquée à la suspension de cellule lorsque la tige de piston mobile est tournée autour de l'axe du corps de récipient. L'extrémité de la tige de piston mobile en contact avec la suspension de cellule est également mobile dans le corps de récipient le long de la direction longitudinale du corps de récipient lors du retrait et de l'expulsion de fluide dans et hors du corps de récipient de centrifugation.
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