Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020117373 - PHARMACEUTICAL COMPOSITIONS COMPRISING ANTI-191P4D12 ANTIBODY DRUG CONJUGATES AND METHODS OF USE THEREOF

Publication Number WO/2020/117373
Publication Date 11.06.2020
International Application No. PCT/US2019/056214
International Filing Date 15.10.2019
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 9/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
08Solutions
A61K 9/19 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
19lyophilised
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Applicants
  • AGENSYS, INC. [US]/[US]
  • SEATTLE GENETICS, INC. [US]/[US]
Inventors
  • MCGAVEY, Orla
  • RATNASWAMY, Gayathri
  • SUN, Yingqing
  • VAN SCHRAVENDIJK, Marie, Rose
Agents
  • MILLER, Elizabeth, Cary
  • ROWAN, Thomas, G.
  • GEORGE, Insogna, M.
  • INSOGNA, Anthony, M.
  • ANTLER, Adriane, M.
Priority Data
62/774,81903.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PHARMACEUTICAL COMPOSITIONS COMPRISING ANTI-191P4D12 ANTIBODY DRUG CONJUGATES AND METHODS OF USE THEREOF
(FR) COMPOSITIONS PHARMACEUTIQUES COMPORTANT DES CONJUGUÉS ANTICORPS ANTI-191P4D12 -MÉDICAMENT ET MÉTHODES D'UTILISATION DE CELLES-CI
Abstract
(EN)
A pharmaceutical composition comprising an antibody drug conjugate comprising an antibody or antigen binding fragment thereof that binds to 191P4D12 conjugated to one or more units of monomethyl auri statin E (MMAE) and a pharmaceutically acceptable excipient comprising L-histidine, polysorbate-20 (TWEEN-20), and at least one of trehalose dihydrate and sucrose.
(FR)
L'invention concerne une composition pharmaceutique qui comporte un conjugué anticorps-médicament qui comprend un anticorps, ou un fragment de liaison à l'antigène de celui-ci, qui se lie à la protéine 191P4D12, conjugué à une ou à plusieurs unités de la monométhylauristatine E (MMAE), ainsi qu'un excipient de qualité pharmaceutique qui comprend de la L-histidine, du polysorbate-20 (TWEEN-20) et au moins l'un des sucres dihydrate de tréhalose et saccharose.
Latest bibliographic data on file with the International Bureau