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1. WO2020117288 - DEUTERATED AGONISTS AND METHODS OF USE

Publication Number WO/2020/117288
Publication Date 11.06.2020
International Application No. PCT/US2019/000064
International Filing Date 15.11.2019
IPC
A61K 31/222 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
222with compounds having aromatic groups, e.g. dipivefrine, ibopamine
A61K 31/225 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
225Polycarboxylic acids
A61K 31/265 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
265of carbonic, thiocarbonic or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
CPC
C07B 2200/05
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
05Isotopically modified compounds, e.g. labelled
C07C 39/19
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
39Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
18monocyclic with unsaturation outside the aromatic ring
19containing carbon-to-carbon double bonds but no carbon-to-carbon triple bonds
Applicants
  • McKINNEY, Jeffrey, A. [US]/[US]
Inventors
  • McKINNEY, Jeffrey, A.
Agents
  • McKINNEY, Jeffrey, A.
Priority Data
62/796,81125.01.2019US
62/797,66628.01.2019US
62/810,21225.02.2019US
62/917,46307.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DEUTERATED AGONISTS AND METHODS OF USE
(FR) AGONISTES DEUTÉRÉS ET LEURS PROCÉDÉS D'UTILISATION
Abstract
(EN)
The present invention is generally directed to deuterated agonists and their methods of use. It is more specifically directed to deuterated alpha-7 nicotinic receptor agonists and their methods of use. In one aspect, the present invention involves compounds of the structure 1-34 as shown in FIGs. 1-4. In another aspect, the present invention involves the treatment of a disorder with a compound of the structure 1-34 as shown in FIGs. 1-4.
(FR)
La présente invention concerne de manière générale des agonistes deutérés et à leurs méthodes d'utilisation. Elle concerne plus particulièrement des agonistes du récepteur nicotinique alpha-7 deutéré et leurs procédés d'utilisation. Dans un aspect, la présente invention concerne des composés de la structure 1-34 comme illustré sur la figure 1-4. Dans un autre aspect, la présente invention concerne le traitement d'un trouble avec un composé de la structure 1-34 comme illustré sur la figure 1-4.
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