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1. WO2020116963 - ENDOTHELIN RECEPTOR TYPE A ACTIVITY REGULATING ANTIBODY

Publication Number WO/2020/116963
Publication Date 11.06.2020
International Application No. PCT/KR2019/017110
International Filing Date 05.12.2019
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
A61P 9/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
12Antihypertensives
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 주식회사 헤지호그 HEDGEHOG, INC. [KR]/[KR]
Inventors
  • 정상택 JUNG, Sang Taek
  • 유연규 YU, Yeon Gyu
  • 주만석 JU, Man-Seok
  • 나정현 NA, Jung-Hyun
  • 김연재 KIM, Youn Jae
  • 안혜미 AHN, Hye-Mi
  • 고병준 KO, Byoung Joon
  • 이원규 LEE, Won Kyu
Agents
  • 특허법인 충현 CHUNG HYUN PATENT & LAW FIRM
Priority Data
10-2018-015531905.12.2018KR
10-2019-015994104.12.2019KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) ENDOTHELIN RECEPTOR TYPE A ACTIVITY REGULATING ANTIBODY
(FR) ANTICORPS DE RÉGULATION DE L'ACTIVITÉ DE TYPE A DU RÉCEPTEUR DE L'ENDOTHÉLINE
(KO) 엔도텔린 수용체 A 활성 조절 항체
Abstract
(EN)
The present invention relates to a monoclonal antibody or a fragment thereof which recognizes the extracellular domain of endothelin receptor type A as an antigen and binds specifically to same. The monoclonal antibody discovered in the present invention can be advantageously used as a therapeutic agent for endothelin receptor type A-related hypertension or cancer.
(FR)
La présente invention concerne un anticorps monoclonal ou un fragment de celui-ci qui reconnaît le domaine extracellulaire du récepteur de l'endothéline de type A en tant qu'antigène et qui se lie spécifiquement à celui-ci. L'anticorps monoclonal découvert dans la présente invention peut être avantageusement utilisé en tant qu'agent thérapeutique pour l'hypertension liée au récepteur de l'endothéline de type A ou au cancer.
(KO)
본 발명은 엔토텔린 수용체 A의 세포외 부위를 항원으로 인식하여 이에 특이적으로 결합하는 단일클론항체 또는 이의 단편에 관한 것이다. 본 발명에서 발굴한 단일클론항체는 엔토텔린 수용체 A와 관련된 고혈압이나 암에 대한 치료제로서 유용하게 활용될 수 있다.
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