Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020116606 - PRODUCTION METHOD FOR T CELLS OR NK CELLS, MEDIUM FOR CULTURING T CELLS OR NK CELLS, METHOD FOR CULTURING T CELLS OR NK CELLS, METHOD FOR MAINTAINING UNDIFFERENTIATED STATE OF UNDIFFERENTIATED T CELLS, AND GROWTH-ACCELERATING AGENT FOR T CELLS OR NK CELLS

Publication Number WO/2020/116606
Publication Date 11.06.2020
International Application No. PCT/JP2019/047808
International Filing Date 06.12.2019
IPC
C12N 5/10 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C12N 15/09 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
CPC
C12N 15/09
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
C12N 5/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
10Cells modified by introduction of foreign genetic material ; Not used, see subgroups
Applicants
  • キリンホールディングス株式会社 KIRIN HOLDINGS KABUSHIKI KAISHA [JP]/[JP]
  • 国立大学法人京都大学 KYOTO UNIVERSITY [JP]/[JP]
Inventors
  • 高柳 晋一郎 TAKAYANAGI Shinichiro
  • 國里 篤志 KUNISATO Atsushi
  • 中観寺 風香 CHUGANJI Sayaka
  • 福本 健 FUKUMOTO Ken
  • 中園 一紀 NAKAZONO Kazuki
  • 金子 新 KANEKO Shin
  • 河合 洋平 KAWAI Yohei
Agents
  • 特許業務法人栄光特許事務所 Eikoh Patent Firm, P.C.
Priority Data
2018-22947806.12.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) PRODUCTION METHOD FOR T CELLS OR NK CELLS, MEDIUM FOR CULTURING T CELLS OR NK CELLS, METHOD FOR CULTURING T CELLS OR NK CELLS, METHOD FOR MAINTAINING UNDIFFERENTIATED STATE OF UNDIFFERENTIATED T CELLS, AND GROWTH-ACCELERATING AGENT FOR T CELLS OR NK CELLS
(FR) PROCÉDÉ DE PRODUCTION DE LYMPHOCYTES T OU DE CELLULES NK, MILIEU DE CULTURE DE LYMPHOCYTES T OU DE CELLULES NK, PROCÉDÉ DE CULTURE DE LYMPHOCYTES T OU DE CELLULES NK, PROCÉDÉ DE MAINTIEN DE L'ÉTAT INDIFFÉRENCIÉ DE LYMPHOCYTES T INDIFFÉRENCIÉS, ET AGENT D'ACCÉLÉRATION DE CROISSANCE POUR LYMPHOCYTES T OU CELLULES NK
(JA) T細胞又はNK細胞の製造方法、T細胞又はNK細胞の培養用培地、T細胞又はNK細胞の培養方法、未分化T細胞の未分化状態を維持する方法及びT細胞又はNK細胞の増殖促進剤
Abstract
(EN)
The purpose of the present invention is to provide a production method for T cells or NK cells, medium for culturing T cells or NK cells, a method for culturing T cells or NK cells, a method for maintaining the undifferentiated state of undifferentiated T cells, and growth-accelerating agent for T cells or NK cells, which enable efficient growth of T cells or NK cells, and enable maintaining of a state (e.g., undifferentiation) of the cells. The present invention pertains to a production method that is for T cells or NK cells and that comprises culturing T cells or NK cells in a medium containing a bisbenzylisoquinoline alkaloid represented by formula (X-1) or formula (X-2) or a compound obtained by cleaving one ether bond thereof or a pharmaceutically acceptable salt thereof, and the like.
(FR)
Procédé de production de lymphocytes T ou de cellules NK, un milieu de culture de lymphocytes T ou de cellules NK, un procédé de culture de lymphocytes T ou de cellules NK, un procédé de maintien de l'état indifférencié de lymphocytes T indifférenciés, et un agent d'accélération de croissance pour des lymphocytes T ou des cellules NK, permettant une croissance efficace de lymphocytes T ou de cellules NK, et permettant le maintien d'un état (par exemple, la non-différenciation) des cellules. La présente invention concerne un procédé de production pour des lymphocytes T ou des cellules NK et comprenant la culture de lymphocytes T ou de cellules NK dans un milieu contenant un alcaloïde de bisbenzylisoquinoline représenté par la formule (X-1) ou la formule (X-2) ou un composé obtenu par clivage d'une liaison éther correspondante ou d'un sel pharmaceutiquement acceptable correspondant, et analogues. <b></b> <b></b>
(JA)
本発明は、T細胞又はNK細胞を効率的に増殖させ、且つ該細胞の状態(例えば未分化性)を維持し得る、T細胞又はNK細胞の製造方法、T細胞又はNK細胞の培養用培地、T細胞又はNK細胞の培養方法、未分化T細胞の未分化状態を維持する方法及びT細胞又はNK細胞の増殖促進剤を提供することを目的とする。 本発明は、式(X-1)又は式(X-2)で表されるビスベンジルイソキノリンアルカロイド若しくは1つのエーテル結合が切断した化合物又はその薬学的に許容される塩を含有する培地中でT細胞又はNK細胞を培養することを含むT細胞又はNK細胞の製造方法等に関する。
Latest bibliographic data on file with the International Bureau