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1. WO2020116589 - METHOD FOR PRODUCING FLUOROVINYL AMIDE COMPOUND

Publication Number WO/2020/116589
Publication Date 11.06.2020
International Application No. PCT/JP2019/047719
International Filing Date 05.12.2019
IPC
C07C 231/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
08from amides by reaction at nitrogen atoms of carboxamide groups
C07C 233/66 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
64having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
66having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
C07D 207/27 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
18having one double bond between ring members or between a ring member and a non-ring member
22with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
24Oxygen or sulfur atoms
262-Pyrrolidones
263with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
27with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
C07D 211/76 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
68having one double bond between ring members or between a ring member and a non-ring member
72with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
74Oxygen atoms
76attached in position 2 or 6
C07B 61/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
61Other general methods
C07D 209/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
44Iso-indoles; Hydrogenated iso-indoles
46with an oxygen atom in position 1
CPC
C07B 61/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
61Other general methods
C07C 231/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
08from amides by reaction at nitrogen atoms of carboxamide groups
C07C 233/66
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
64having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
66having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
C07D 207/27
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
18having one double bond between ring members or between a ring member and a non-ring member
22with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
24Oxygen or sulfur atoms
262-Pyrrolidones
263with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
27with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
C07D 209/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
44Iso-indoles; Hydrogenated iso-indoles
46with an oxygen atom in position 1
C07D 211/76
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
68having one double bond between ring members or between a ring member and a non-ring member
72with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
74Oxygen atoms
76attached in position 2 or 6
Applicants
  • ダイキン工業株式会社 DAIKIN INDUSTRIES, LTD. [JP]/[JP]
Inventors
  • 星谷 尚亨 HOSHIYA, Naoyuki
  • 松井 元志 MATSUI, Motoshi
  • 岸川 洋介 KISHIKAWA, Yosuke
Agents
  • 特許業務法人三枝国際特許事務所 SAEGUSA & PARTNERS
Priority Data
2018-22858905.12.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR PRODUCING FLUOROVINYL AMIDE COMPOUND
(FR) PROCÉDÉ DE PRODUCTION D'UN COMPOSÉ AMIDE FLUOROVINYLIQUE
(JA) フルオロビニルアミド化合物の製造方法
Abstract
(EN)
The purpose of the present disclosure is to provide a novel method for producing a fluorovinyl amide compound. The purpose is achieved by means of a method for producing a compound represented by formula (I) [in the formula, Rf is -F or fluoroalkyl, and Ra1 is -H or an organic group and Ra2 is -H or an organic group, or (i) Ra1 and Ra2, (ii) Ra1 and Rf, or (iii) Rf and Ra2 may be linked, and Rb1 is -H or an organic group and Rb2 is -H or an organic group, or Rb1 and Rb2 may be linked together with atoms, which are respectively adjacent to Rb1 and Rb2, to form a nitrogen-containing ring that may have at least one substituent], the method comprising step A for reacting a compound represented by formula (2) [in the formula, Rx is a leaving group, and other symbols are as defined above] with a compound represented by formula (3) [in the formula, symbols are as defined above] or a salt thereof in the presence of a transition metal catalyst.
(FR)
L'objet de la présente invention est de fournir un nouveau procédé de production d'un composé amide fluorovinylique. La solution selon l'invention concerne un procédé de production d'un composé représenté par la formule (I) [dans La formule, Rf est -F ou fluoroalkyle, et Ra1 représente -H ou un groupe organique et Ra2 représente -H ou un groupe organique, ou (i) Ra1 et Ra2, (ii) Ra1 et Rf, ou (iii) Rf et Ra2 peuvent être liés, et Rb1 est -H ou un groupe organique et Rb2 est -H ou un groupe organique, ou Rb1 et Rb2 peuvent être liés ensemble avec des atomes, qui sont respectivement adjacents à Rb1 et Rb2, pour former un cycle contenant de l'azote qui peut avoir au moins un substituant], le procédé comprenant une étape A consistant à faire réagir un composé représenté par la formule (2) [dans la formule, Rx est un groupe partant, et les autres symboles sont tels que définis ci-dessus] avec un composé représenté par la formule (3) [dans la formule, les symboles sont tels que définis ci-dessus] ou un sel de celui-ci en présence d'un catalyseur de métal de transition.
(JA)
本開示は、フルオロビニルアミド化合物の新たな製造方法等を提供することを目的とする。 前記目的は、式(1):[式中、 Rfは、-F、又はフルオロアルキルであり、及び Ra1は、-H、又は有機基であり、 Ra2は、-H、又は有機基であるか、或いは (i)Ra1及びRa2、(ii)Ra1及びRf、又は(iii)Rf及びRa2が、連結していてもよく、 Rb1は、-H、又は有機基であり、及び Rb2は、-H、又は有機基であるか、或いは Rb1、及びRb2は、これらがそれぞれ隣接する原子と一緒になって、連結し、1個以上の置換基を有していてもよい含窒素環を形成していてもよい。] で表される化合物の製造方法であって、 式(2):[式中、 Rは、脱離基であり、及び その他の記号は、前記と同意義である。] で表される化合物を、 遷移金属触媒の存在下で、 式(3):[式中の記号は、前記と同意義である。] で表される化合物又はその塩と、 反応させる工程A を含む製造方法 によって達成される。
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