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1. WO2020116587 - POLYMER MICELLE CARRIER COMPOSITION AND MEDICINE-CONTAINING POLYMER MICELLE COMPOSITION

Publication Number WO/2020/116587
Publication Date 11.06.2020
International Application No. PCT/JP2019/047712
International Filing Date 05.12.2019
IPC
A61K 45/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A61P 17/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
14for baldness or alopecia
A61Q 19/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
A61K 9/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
A61K 8/86 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
72containing organic macromolecular compounds
84obtained by reactions other than those involving only carbon-to-carbon unsaturated bonds
86Polyethers
Applicants
  • ナノキャリア株式会社 NANOCARRIER CO., LTD. [JP]/[JP]
Inventors
  • 四本 健介 YOTSUMOTO, Kensuke
  • 小久保 美穂 KOKUBO, Miho
  • 安岡 佐季子 YASUOKA, Sakiko
Agents
  • 青木 篤 AOKI, Atsushi
  • 三橋 真二 MITSUHASHI, Shinji
  • 中島 勝 NAKAJIMA, Masaru
  • 渡辺 陽一 WATANABE, Yoichi
  • 関根 宣夫 SEKINE, Nobuo
Priority Data
2018-22846105.12.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) POLYMER MICELLE CARRIER COMPOSITION AND MEDICINE-CONTAINING POLYMER MICELLE COMPOSITION
(FR) COMPOSITION DE VECTEUR MICELLAIRE POLYMÈRE ET COMPOSITION DE MICELLE POLYMÈRE CONTENANT UN MÉDICAMENT
(JA) ポリマーミセル担体組成物及び薬物含有ポリマーミセル組成物
Abstract
(EN)
Provided are a polymer micelle carrier composition and a medicine-containing polymer micelle composition that enable improvement of efficiency of penetration of a medicine to the skin. This polymer micelle carrier composition includes: an aqueous medium; and a block copolymer that forms a polymer micelle structure in the aqueous medium and that has a hydrophilic polymer chain segment and a hydrophobic polymer chain segment. The polymer micelle carrier composition further contains a penetration accelerator at concentration a such that the contact angle ratio calculated according to formula A is less than or equal to 0.82.
(FR)
L'invention concerne une composition de vecteur micellaire polymère et une composition de micelle polymère contenant un médicament qui permettent d'améliorer l'efficacité de pénétration d'un médicament à travers la peau. Ladite composition de vecteur micellaire polymère comprend : un milieu aqueux; et un copolymère séquencé qui forme une structure micellaire polymère dans le milieu aqueux et qui a un segment de chaîne polymère hydrophile et un segment de chaîne polymère hydrophobe. La composition de vecteur micellaire polymère contient en outre un accélérateur de pénétration à une concentration telle que le rapport d'angle de contact calculé selon la formule A est inférieur ou égal à 0,82.
(JA)
薬物の皮膚への浸透効率を向上できるポリマーミセル担体組成物及び薬物含有ポリマーミセル組成物を提供する。 水性媒体と、前記水性媒体中でポリマーミセル構造を形成する、親水性ポリマー鎖セグメント及び疎水性ポリマー鎖セグメントを有するブロックコポリマーとを含むポリマーミセル担体組成物であって、更に浸透促進剤を、後記式Aで算出される接触角比が0.82以下となる濃度aで含有する。 接触角比=(浸透促進剤を濃度aで含有する水溶液の接触角)/(水の接触角)・・・式A
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