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1. WO2020116498 - CXCR3 LIGAND

Publication Number WO/2020/116498
Publication Date 11.06.2020
International Application No. PCT/JP2019/047382
International Filing Date 04.12.2019
IPC
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61P 37/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C07K 14/52 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
C07K 19/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
C12P 21/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
Applicants
  • 中外製薬株式会社 CHUGAI SEIYAKU KABUSHIKI KAISHA [JP]/[JP]
Inventors
  • 山本 陽平 YAMAMOTO, Yohei
  • 櫻井 実香 SAKURAI, Mika
  • 原谷 健太 HARAYA, Kenta
Agents
  • 春名 雅夫 HARUNA, Masao
  • 清水 初志 SHIMIZU, Hatsushi
  • 山口 裕孝 YAMAGUCHI, Hirotaka
  • 刑部 俊 OSAKABE, Suguru
  • 井上 隆一 INOUE, Ryuichi
  • 佐藤 利光 SATO, Toshimitsu
  • 新見 浩一 SHIMMI, Hirokazu
  • 小林 智彦 KOBAYASHI, Tomohiko
  • 小寺 秀紀 KODERA, Hideki
  • 大関 雅人 OHZEKI, Masato
  • 五十嵐 義弘 IGARASHI, Yoshihiro
  • 川本 和弥 KAWAMOTO, Kazuya
Priority Data
2018-22735304.12.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) CXCR3 LIGAND
(FR) LIGAND DE CXCR3
(JA) CXCR3リガンド
Abstract
(EN)
The present disclosure relates to a CXCR3 ligand having DPPIV resistance and CXCR3-expressing cell migration activity, and specifically relates to the N-terminal amino acid modification and the N-terminal amino acid sequence that are important for DPPIV resistance and CXCR3-expressing cell migration activity.
(FR)
La présente invention concerne un ligand de CXCR3 présentant une résistance à la DPP-IV et une activité de migration cellulaire exprimant le CXCR3, et concerne spécifiquement la modification d'acides aminés N-terminaux et la séquence d'acides aminés N-terminaux qui sont importantes pour la résistance à la DPP-IV et l'activité de migration cellulaire exprimant le CXCR3.
(JA)
本開示は、DPPIVに対する耐性及びCXCR3発現細胞遊走活性を有するCXCR3リガンドに関し、具体的に、DPPIVに対する耐性及びCXCR3発現細胞遊走活性に重要なN末端アミノ酸改変及びN末端アミノ酸配列に関する。
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