Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020116423 - ANTIBODY THAT RECOGNIZES NEOEPITOPE OF ACTIVATED INTERLEUKIN-18 PROTEINS AND APPLICATION THEREOF

Publication Number WO/2020/116423
Publication Date 11.06.2020
International Application No. PCT/JP2019/047154
International Filing Date 03.12.2019
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61P 37/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
C07K 16/24 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
C12P 21/08 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
08Monoclonal antibodies
C12N 15/13 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
CPC
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 37/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
C07K 16/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
G01N 33/53
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
G01N 33/531
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
531Production of immunochemical test materials
Applicants
  • 株式会社mAbProtein MABPROTEIN CO.,LTD. [JP]/[JP]
Inventors
  • 浦野 健 URANO Takeshi
  • 成相 裕子 NARIAI Yuko
  • 加美野 宏樹 KAMINO Hiroki
  • 尾林 栄治 OBAYASHI Eiji
Agents
  • 白形 由美子 SHIRAKATA Yumiko
Priority Data
2018-22666703.12.2018JP
2019-10482604.06.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) ANTIBODY THAT RECOGNIZES NEOEPITOPE OF ACTIVATED INTERLEUKIN-18 PROTEINS AND APPLICATION THEREOF
(FR) ANTICORPS RECONNAISSANT UN NÉO-ÉPITOPE DE PROTÉINES DE L'INTERLEUKINE-18 ACTIVÉE ET APPLICATION ASSOCIÉE
(JA) 活性型インターロイキン-18タンパク質のネオエピトープを認識する抗体、及びその応用
Abstract
(EN)
In the present invention, prepared are a 9-10.2 antibody and an 8-4.1 antibody that recognize eight amino acids, YFGKLESK, present in the neoepitope formed as a result of a precursor pro-IL-18 being cleaved by caspase-1 or caspase-4. The present invention can provide antibodies that only recognize activated IL-18.
(FR)
La présente invention concerne la préparation d'un anticorps 9-10.2 et d'un anticorps 8-4.1 qui reconnaissent huit acides aminés, YFGKLESK, présents dans le néo-épitope formé suite au clivage d'un précurseur pro-IL-18 par la caspase-1 ou la caspase-4. La présente invention peut fournir des anticorps qui ne reconnaissent que l'IL -18 activée.
(JA)
前駆体であるpro-IL-18が、caspase-1、あるいはcaspase-4によって切断され、形成されるネオエピトープに存在する8アミノ酸、YFGKLESKを認識する9-10.2抗体、及び8-4.1抗体を作製した。活性型IL-18のみを認識する抗体を提供することができる。
Latest bibliographic data on file with the International Bureau