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1. WO2020116398 - ANTI-IGF-I RECEPTOR HUMANIZED ANTIBODY

Publication Number WO/2020/116398
Publication Date 11.06.2020
International Application No. PCT/JP2019/047050
International Filing Date 02.12.2019
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C12P 21/08 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
08Monoclonal antibodies
A61K 35/12 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
C12N 5/10 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
Applicants
  • 帝人ファーマ株式会社 TEIJIN PHARMA LIMITED [JP]/[JP]
  • KMバイオロジクス株式会社 KM BIOLOGICS CO., LTD. [JP]/[JP]
Inventors
  • 田野倉 章 TANOKURA, Akira
  • 加藤 浩嗣 KATO, Hirotsugu
  • 江口 広志 EGUCHI, Hiroshi
  • 高木 健一郎 TAKAGI, Kenichiro
  • 山村 聡 YAMAMURA, Satoshi
  • 並木 直子 NAMIKI, Naoko
  • 石川 大輔 ISHIKAWA, Daisuke
  • 樋口 浩文 HIGUCHI, Hirofumi
  • 竹尾 智予 TAKEO, Tomoyo
  • 大堀 真代 OHORI, Masayo
Agents
  • 青木 篤 AOKI, Atsushi
  • 三橋 真二 MITSUHASHI, Shinji
  • 中島 勝 NAKAJIMA, Masaru
  • 渡辺 陽一 WATANABE, Yoichi
  • 関根 宣夫 SEKINE, Nobuo
Priority Data
2018-22666903.12.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) ANTI-IGF-I RECEPTOR HUMANIZED ANTIBODY
(FR) ANTICORPS HUMANISÉ ANTI-RÉCEPTEUR DE L'IGF-I
(JA) 抗IGF-I受容体ヒト化抗体
Abstract
(EN)
Provided is a humanized antibody that, through IGF-I receptor, increases muscle mass but does not lower the blood glucose level. This humanized antibody: is an anti-IGF-I receptor humanized antibody, a fragment thereof, or a derivative thereof; has a specific amino acid sequence such as SEQ ID NOs: 1 to 6 serving as a CDR sequence; and specifically binds to IGF-I receptor extracellular domain.
(FR)
L'invention concerne un anticorps humanisé qui, par l'intermédiaire du récepteur de l'IGF-I, augmente la masse musculaire mais ne diminue pas le taux de glycémie. Cet anticorps humanisé : est un anticorps humanisé anti-récepteur de l'IGF-I, un fragment de celui-ci ou un dérivé de celui-ci; a une séquence d'acides aminés spécifique telle que les SEQ ID No. : 1 à 6 servant de séquence de CDR; et se lie spécifiquement au domaine extracellulaire du récepteur de l'IGF-I.
(JA)
IGF-I受容体を介して、筋肉量を増加させるが、血糖値を低下させないヒト化抗体を提供する。斯かるヒト化抗体は、各CDR配列としてそれぞれ配列番号1~6等の特定のアミノ酸配列を有し、IGF-I受容体の細胞外ドメインに特異的に結合する、抗IGF-I受容体ヒト化抗体若しくはその断片、又はそれらの誘導体である。
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