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1. WO2020115765 - NOVEL SYNERGISTIC COMPOSITION COMPRISING SIRT1 AND AMPK ACTIVATORS FOR TREATING METABOLIC SYNDROME

Publication Number WO/2020/115765
Publication Date 11.06.2020
International Application No. PCT/IN2019/050885
International Filing Date 05.12.2019
IPC
A61K 9/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
A61K 9/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
A61K 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
CPC
A61K 31/194
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
194having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
A61K 31/375
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
375Ascorbic acid, i.e. vitamin C; Salts thereof
A61K 31/455
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
455Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
A61K 9/2018
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2013Organic compounds, e.g. phospholipids, fats
2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
A61K 9/2027
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2022Organic macromolecular compounds
2027obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
A61K 9/2054
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2022Organic macromolecular compounds
205Polysaccharides, e.g. alginate, gums; Cyclodextrin
2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Applicants
  • CELAGENEX RESEARCH (INDIA) PVT. LTD. [IN]/[IN]
Inventors
  • DHAMANE, Dhiraj
  • PRASAD T., Rajendra
Agents
  • SINGH, Manisha
Priority Data
20182104588405.12.2018IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL SYNERGISTIC COMPOSITION COMPRISING SIRT1 AND AMPK ACTIVATORS FOR TREATING METABOLIC SYNDROME
(FR) NOUVELLE COMPOSITION SYNERGIQUE COMPRENANT DES ACTIVATEURS DE SIRT1 ET D'AMPK POUR LE TRAITEMENT DU SYNDROME MÉTABOLIQUE
Abstract
(EN)
The present invention herein discloses novel synergistic composition comprising SIRT1 and AMPK activators for treating metabolic syndrome. Particularly the composition comprising therapeutic blend of SIRT1 activator(s) and stabilized AMPK activator(s) present in the ratio of 1: 1 to 1: 5, along with pharmaceutically acceptable excipients. More particularly the invention discloses novel synergistic nutritional composition comprising synergistic combination of N1-methylnicotinamide salt to oxaloacetic acid to standardized ascorbic acid present in the ratio ranges from 1:1:1 to 1:2:2, more particularly 1: 1.1: 1.6. The present synergistic nutritional compositions are useful for treating a subject suffering from metabolic syndrome such as hypertension, obesity, hyperlipidemia and diabetes and other related cardiovascular diseases. Further it improves ATP level and antioxidant activity.
(FR)
La présente invention concerne une nouvelle composition synergique comprenant des activateurs de SIRT1 et d'AMPK pour le traitement du syndrome métabolique. En particulier, la composition comprend un mélange thérapeutique d'un ou plusieurs activateurs de SIRT1 et d'un ou plusieurs activateurs d'AMPK stabilisés présents dans le rapport de 1: 1 à 1: 5, ainsi que des excipients pharmaceutiquement acceptables. 10. Plus particulièrement, l'invention concerne une nouvelle composition nutritionnelle synergique comprenant une combinaison synergique de sel de N1-méthylnicotinamide à l'acide oxaloacétique à l'acide ascorbique standardisé présents dans le rapport allant de 1:1:1 à 1:2:2, plus particulièrement 1: 1,1: 1,6. Les présentes compositions nutritionnelles synergiques sont utiles pour traiter un sujet souffrant de syndrome métabolique tel que l'hypertension, l'obésité, l'hyperlipidémie et le diabète et d'autres maladies cardiovasculaires associées. En outre, elle améliore le taux d'ATP et l'activité antioxydante.
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