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1. WO2020115720 - OPTICAL IMAGING BASED ON SPECTRAL SHIFT ASSESSMENT

Publication Number WO/2020/115720
Publication Date 11.06.2020
International Application No. PCT/IB2019/060540
International Filing Date 08.12.2019
IPC
G01J 3/00 2006.01
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
G01N 21/00 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
CPC
G01N 21/6402
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
6402Atomic fluorescence; Laser induced fluorescence
G01N 21/6458
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
645Specially adapted constructive features of fluorimeters
6456Spatial resolved fluorescence measurements; Imaging
6458Fluorescence microscopy
G01N 2201/06113
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2201Features of devices classified in G01N21/00
06Illumination; Optics
061Sources
06113Coherent sources; lasers
G01N 2201/126
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2201Features of devices classified in G01N21/00
12Circuits of general importance; Signal processing
126Microprocessor processing
G02B 21/0076
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
0004specially adapted for specific applications
002Scanning microscopes
0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
0052Optical details of the image generation
0076arrangements using fluorescence or luminescence
G02B 21/16
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
16adapted for ultra-violet illumination ; ; Fluorescence microscopes
Applicants
  • PARVIN, Parviz [IR]/[IR]
  • JAFARGHOLI, Amir [IR]/[IR]
  • BAVALI, Ali [IR]/[IR]
  • BASSAM, Mohammad Amin [IR]/[IR]
  • ZHALEFAR, Parisa [IR]/[IR]
  • NIAZI, Azadeh [IR]/[IR]
  • DEHGHANIAN, Seyed Ali [IR]/[IR]
  • KHODABAKSHI, Zahra [IR]/[IR]
Inventors
  • PARVIN, Parviz
  • JAFARGHOLI, Amir
  • BAVALI, Ali
  • BASSAM, Mohammad Amin
  • ZHALEFAR, Parisa
  • NIAZI, Azadeh
  • DEHGHANIAN, Seyed Ali
  • KHODABAKSHI, Zahra
Agents
  • IDESAZAN ASR AFTAB
Priority Data
62/777,07408.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) OPTICAL IMAGING BASED ON SPECTRAL SHIFT ASSESSMENT
(FR) IMAGERIE OPTIQUE BASÉE SUR UNE ÉVALUATION DE DÉCALAGE SPECTRAL
Abstract
(EN)
A method for optical imaging based on spectral shift assessment. The method includes generating a sample by mixing an object with a fluorophore, stimulating the sample by emitting a laser beam, extracting a plurality of fluorescence spectra from a plurality of fluorescence emissions emitted from the sample, detecting a plurality of fluorescence peaks and a plurality of peak wavelengths in the plurality of fluorescence spectra, extracting a plurality of fluorophore concentrations from a database, and generating a concentration image. The plurality of peak wavelengths are detected by detecting a respective peak wavelength of the plurality of peak wavelengths. Each of the plurality of fluorophore concentrations is associated with a respective peak wavelength of the plurality of peak wavelengths. The concentration image includes a first plurality of pixels. The concentration image is generated based on a respective fluorophore concentration of the plurality of fluorophore concentrations.
(FR)
La présente invention concerne un procédé d'imagerie optique basé sur une évaluation de décalage spectral. Le procédé comprend la génération d'un échantillon par mélange d'un objet avec un fluorophore, la stimulation de l'échantillon par émission d'un faisceau laser, l'extraction d'une pluralité de spectres de fluorescence d'une pluralité d'émissions de fluorescence émises à partir de l'échantillon, la détection d'une pluralité de pics de fluorescence et d'une pluralité de longueurs d'onde de pic dans la pluralité de spectres de fluorescence, l'extraction d'une pluralité de concentrations de fluorophore à partir d'une base de données et la génération d'une image de concentration. La pluralité de longueurs d'onde de pic est détectée par détection d'une longueur d'onde de pic correspondante de la pluralité de longueurs d'onde de pic. Chacune des concentrations de la pluralité de concentrations de fluorophore est associée à une longueur d'onde de pic correspondante de la pluralité de longueurs d'onde de pic. L'image de concentration comprend une première pluralité de pixels. L'image de concentration est générée sur la base d'une concentration de fluorophore correspondante de la pluralité de concentrations de fluorophore.
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