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1. WO2020115655 - CELLS WITH REDUCED INHIBITOR PRODUCTION AND METHODS OF USE THEREOF

Publication Number WO/2020/115655
Publication Date 11.06.2020
International Application No. PCT/IB2019/060398
International Filing Date 03.12.2019
IPC
C12P 21/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
C12N 15/09 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
CPC
C12N 15/09
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
C12P 21/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
02having a known sequence of two or more amino acids, e.g. glutathione
Applicants
  • PFIZER INC. [US]/[US]
Inventors
  • DEUTSCHMAN, Emily Ann
  • MULUKUTLA, Bhanu Chandra
  • MITCHELL, Jeffrey Joseph
  • SCARCELLI, John Joseph
Agents
  • ZIELINSKI, Bryan C.
Priority Data
62/776,19006.12.2018US
62/932,09607.11.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CELLS WITH REDUCED INHIBITOR PRODUCTION AND METHODS OF USE THEREOF
(FR) CELLULES Ã PRODUCTION RÉDUITE D'INHIBITEURS ET PROCÉDÉS D'UTILISATIONS CORRESPONDANTS
Abstract
(EN)
The invention relates to a method of cell culture where the cells are modified to reduce the level of synthesis of growth and/or productivity inhibitors by the cell. The invention also relates to a method of cell culture for improving cell growth and productivity, in particular in culture of mammalian cells at high cell density. The invention further relates to a method of producing cells with improved cell growth and/or productivity in cell culture and to cells obtained or obtainable by such methods.
(FR)
Procédé de culture cellulaire permettant de modifier des cellules pour réduire le niveau de synthèse d'inhibiteurs de croissance et/ou de productivité par la cellule. L'invention porte également sur un procédé de culture cellulaire destiné à améliorer la croissance cellulaire et la productivité, en particulier dans une culture de cellules de mammifères à haute densité cellulaire. L'invention concerne en outre un procédé de production de cellules présentant une croissance cellulaire et/ou une productivité améliorée(s) dans une culture cellulaire, et les cellules obtenues ou pouvant être obtenues par de tels procédés.
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