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1. WO2020115555 - CRF1 RECEPTOR ANTAGONIST, PHARMACEUTICAL FORMULATIONS AND SOLID FORMS THEREOF FOR THE TREATMENT OF CONGENITAL ADRENAL HYPERPLASIA

Publication Number WO/2020/115555
Publication Date 11.06.2020
International Application No. PCT/IB2019/001325
International Filing Date 06.12.2019
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 31/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
CPC
A61K 31/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A61K 9/0095
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0087Galenical forms not covered by A61K9/02 - A61K9/7023
0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Applicants
  • NEUROCRINE BIOSCIENCES, INC. [US]/[US]
  • SANOFI [FR]/[FR]
Inventors
  • FARBER, Robert H.
  • LOEWEN, Gordon Raphael
  • ZHANG, Xiaoping
  • GIRI, Nagdeep
  • CHAN, Jean L.
  • STIRN, Scott
  • SAYERS, Brian
  • TAYLOR, Graeme
  • COSTA, Christina Marie
  • PARKS, Stacy
  • VICKERY, Anthony D.
  • DOWNING, Kristie M.
  • IYOHA, Kingsley
  • NGWENYA-JONES, Ayanda
  • CHARLIER, Anne
  • MEHTON, Gurvinder Singh
Agents
  • BOYLE, Craig D.
Priority Data
62/776,76307.12.2018US
62/816,67411.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CRF1 RECEPTOR ANTAGONIST, PHARMACEUTICAL FORMULATIONS AND SOLID FORMS THEREOF FOR THE TREATMENT OF CONGENITAL ADRENAL HYPERPLASIA
(FR) ANTAGONISTE DU RÉCEPTEUR CRF1, FORMULATIONS PHARMACEUTIQUES ET FORMES SOLIDES CORRESPONDANTES POUR LE TRAITEMENT DE L'HYPERPLASIE SURRÉNALIENNE CONGÉNITALE
Abstract
(EN)
Provided are methods related to treating congenital adrenal hyperplasia in a subject in need thereof comprising administering 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[( 1 S)-2-cyclopropyl- 1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-l,3-thiazol-2-amine (Formula 1), or a pharmaceutically acceptable salt thereof. Further provided are pharmaceutical formulations and solid forms of 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(lS)-2-cyclopropyl-l-(3-fluoro-4-methylphenyl)ethyl]-5-mcthyl-N -prop-2 -ynyl-l,3-thiazol-2-amine, or a pharmaceutically acceptable salt thereof, and their use in the treatment of congenital adrenal hyperplasia (CAH).
(FR)
L'invention concerne des méthodes liés au traitement de l'hyperplasie surrénalienne congénitale chez un sujet en ayant besoin, comprenant l'administration de 4-(2-chloro-4-méthoxy-5-méthylphényl)-N- [(1S)-2-cyclopropyl-1-(3-fluoro-4-méthylphényl)éthyl]-5-méthyl-N-prop-2-ynyl-l,3-thiazol-2-amine (formule 1), ou un sel pharmaceutiquement acceptable de celui-ci. L'invention concerne également des formulations pharmaceutiques et des formes solides de 4-(2-chloro-4-méthoxy-5-méthylphényl)-N- [(lS)-2-cyclopropyl-l- (3-fluoro-4-méthylphényl)-N- [(lS)-2-cyclopropyl-l- (3-fluoro-4-méthylphényl))éthyl]-5-mcthyl-N-prop-2-ynyl-l,3-thiazol-2-amine, ou un sel pharmaceutiquement acceptable de celui-ci, et leur utilisation dans le traitement de l'hyperplasie surrénaliene congénitale (CAH).
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