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1. WO2020115510 - OCULAR HYDROGEL COMPOSITIONS

Publication Number WO/2020/115510
Publication Date 11.06.2020
International Application No. PCT/GB2019/053479
International Filing Date 09.12.2019
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 47/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
02Inorganic compounds
A61K 47/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
CPC
A61K 47/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
02Inorganic compounds
A61K 47/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 9/0014
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0014Skin, i.e. galenical aspects of topical compositions
A61K 9/0048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0048Eye, e.g. artificial tears
Applicants
  • THE UNIVERSITY OF BIRMINGHAM [GB]/[GB]
Inventors
  • GROVER, Liam
  • METCALFE, Anthony
  • WILLIAMS, Richard
  • MOAKES, Richard
Agents
  • HGF LIMITED
Priority Data
1820021.207.12.2018GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) OCULAR HYDROGEL COMPOSITIONS
(FR) COMPOSITIONS D'HYDROGEL OCULAIRES
Abstract
(EN)
Provided are shear-thinning ocular hydrogel compositions that comprise 0.1 to 5.0 wt.% (e.g. 0.1 to 3.5 wt.% or 0.1 to 2.5wt.%) of a microgel particle-forming polymer; and 0.5 to 100mM of a monovalent and/or polyvalent metal ion salt as a cross-linking agent; dispersed in an aqueous vehicle. The hydrogel compositions have a pH within the range of 3 to 8 and the viscosity of the gel composition reduces when the gel is exposed to shear. The compositions comprise decorin. The may also comprise an antibiotic, such as gentamicin, and an anti- inflammatory steroid, such as prednisolone. The compositions are suitable for medical use in the treatment of the eye. For example, the compositions are suitable for use in the inhibition of scarring and/or the prevention or treatment of microbial keratitis.
(FR)
La présente invention concerne des compositions d'hydrogel oculaires rhéofluidifiantes qui comprennent 0,1 à 5,0 % en poids (par exemple 0,1 à 3,5 % en poids ou 0,1 à 2,5 % en poids) d'un polymère formant des particules de microgel ; et 0,5 à 100 mM d'un sel d'ion métallique monovalent et/ou polyvalent en tant qu'agent de réticulation ; dispersés dans un véhicule aqueux. Les compositions d'hydrogel ont un pH dans la plage de 3 à 8 et la viscosité de la composition de gel diminue lorsque le gel est exposé à un cisaillement. Les compositions comprennent de la décorine. Les compositions peuvent également comprendre un antibiotique comme la gentamicine, et un anti-inflammatoire stéroïdien comme la prednisolone. Les compositions sont adaptées à un usage médical destiné au traitement de l’œil. Par exemple, les compositions sont adaptées à un usage destiné à la cicatrisation et/ou la prévention ou au traitement de la kératite microbienne.
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