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1. WO2020115508 - THERAPEUTIC HYDROGEL COMPOSITIONS

Publication Number WO/2020/115508
Publication Date 11.06.2020
International Application No. PCT/GB2019/053476
International Filing Date 09.12.2019
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 47/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
02Inorganic compounds
A61K 47/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
CPC
A61K 47/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
02Inorganic compounds
A61K 47/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 9/0014
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0014Skin, i.e. galenical aspects of topical compositions
A61K 9/0048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0048Eye, e.g. artificial tears
Applicants
  • THE UNIVERSITY OF BIRMINGHAM [GB]/[GB]
Inventors
  • GROVER, Liam
  • METCALFE, Anthony
  • WILLIAMS, Richard
  • MOAKES, Richard
Agents
  • HGF LIMITED
Priority Data
1820018.807.12.2018GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THERAPEUTIC HYDROGEL COMPOSITIONS
(FR) COMPOSITIONS D’HYDROGEL THÉRAPEUTIQUES
Abstract
(EN)
Disclosed are shear-thinning hydrogel compositions comprising 0.1 to 5wt.% (such as 0.1 to 2.5wt.%) of a microgel particle-forming polymer; and 0.5 to 100mM of a monovalent and/or polyvalent metal ion salt as a cross-linking agent. The microgel particle-forming polymer is dispersed in an aqueous vehicle, and the hydrogel composition has a pH within the range of 3 to 8. The viscosity of the gel composition reduces when the gel is exposed to shear. Also disclosed are methods of making such compositions, and medical uses of such compositions.
(FR)
La présente invention concerne des compositions d’hydrogel à fluidification par cisaillement comprenant de 0,1 à 5 % en pds (tel que de 0,1 à 2,5 % en pds) d’un polymère de formation de particules de microgel ; et de 0,5 à 100 mM d’un sel d’ion métallique monovalent et/ou polyvalent en tant qu'agent de réticulation. Le polymère de formation de particules de microgel est dispersé dans un véhicule aqueux, et la composition d’hydrogel présente un pH situé à l’intérieur de la plage de 3 à 8. La viscosité de la composition de gel diminue lorsque le gel est exposé à un cisaillement. L’invention concerne également des procédés de fabrication de telles compositions, et les utilisations médicales de telles compositions.
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