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1. WO2020115503 - WOUND TREATMENT GEL OBTAINABLE BY COMBINING PLATELET RICH PLASMA WITH AUTOLOGOUSLY DERIVED THROMBIN

Publication Number WO/2020/115503
Publication Date 11.06.2020
International Application No. PCT/GB2019/053460
International Filing Date 06.12.2019
IPC
A61K 35/16 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
16Blood plasma; Blood serum
A61K 35/19 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
19Platelets; Megacaryocytes
A61L 24/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
04containing macromolecular materials
10Polypeptides; Proteins
A61P 17/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
02for treating wounds, ulcers, burns, scars, keloids, or the like
CPC
A61K 35/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
16Blood plasma; Blood serum
A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61K 35/19
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
19Platelets; Megacaryocytes
A61K 38/4833
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
482Serine endopeptidases (3.4.21)
4833Thrombin (3.4.21.5)
A61L 26/0047
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
26Chemical aspects of, or use of materials for, ; wound dressings or; bandages ; in liquid, gel or powder form
0009containing macromolecular materials
0028Polypeptides; Proteins; Degradation products thereof
0047Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
A61L 26/0057
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
26Chemical aspects of, or use of materials for, ; wound dressings or; bandages ; in liquid, gel or powder form
0057Ingredients of undetermined constitution or reaction products thereof
Applicants
  • BIOTHERAPY SERVICES LIMITED [GB]/[GB]
Inventors
  • HADFIELD, Janet
Agents
  • GILL JENNINGS & EVERY LLP
Priority Data
1819987.707.12.2018GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) WOUND TREATMENT GEL OBTAINABLE BY COMBINING PLATELET RICH PLASMA WITH AUTOLOGOUSLY DERIVED THROMBIN
(FR) GEL DE TRAITEMENT DE PLAIE POUVANT ÊTRE OBTENU PAR LA COMBINAISON D'UN PLASMA RICHE EN PLAQUETTES AVEC DE LA THROMBINE DÉRIVÉE DE MANIÈRE AUTOLOGUE
Abstract
(EN)
The present invention provides a method of making a wound treatment composition, wherein the method comprises; i) fractionating a whole blood sample into multiple samples including a platelet rich plasma (PRP) sample,a platelet poor plasma (PPP) sample and a erythrocyte sample, wherein the PRP sample has a haematocrit level of 1-10%, ii) processing a portion of the PPP and/or PRP sample to facilitate cleavage of autologous pro-thrombin present in the PPP and/or PRP to produce autologous thrombin, and iii) combining the PRP sample with a portion of the PPP sample and a portion of the thrombin produced in step (ii) to produce the wound treatment composition; wherein step ii) is performed at less than 15 °C. In preferred embodiments the PRP has a haematocrit level of 2 or 8%. Wound treatment compositions produced by the methods are also provided as are compositions for use in treating chronic and acute wounds.
(FR)
La présente invention concerne un procédé de fabrication d'une composition de traitement de plaie, le procédé comprenant les étapes consistant à : i) fractionner un échantillon de sang total en de multiples échantillons comprenant un échantillon de plasma riche en plaquettes (PRP), un échantillon de plasma pauvre en plaquettes (PPP) et un échantillon d'érythrocytes, l'échantillon PRP ayant un taux d'hématocrite de 1 à 10 %, ii) traiter une partie de l'échantillon PPP et/ou de l'échantillon PRP pour faciliter le clivage de prothrombine autologue présente dans le PPP et/ou le PRP pour produire de la thrombine autologue, et iii) combiner l'échantillon PRP avec une partie de l'échantillon PPP et une partie de la thrombine produite à l'étape (ii) afin de produire la composition de traitement de plaie ; l'étape ii) étant effectuée à moins de 15 °C. Dans des modes de réalisation préférés, le PRP a un taux d'hématocrite de 2 ou 8 %. L'invention concerne également des compositions de traitement de plaie produites par les procédés, ainsi que des compositions destinées à être utilisées dans le traitement de plaies chroniques et aiguës.
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