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1. WO2020115494 - LINKERS

Publication Number WO/2020/115494
Publication Date 11.06.2020
International Application No. PCT/GB2019/053445
International Filing Date 06.12.2019
IPC
A61K 47/64 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
CPC
A61K 47/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 47/645
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
645Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
Applicants
  • OXFORD UNIVERSITY INNOVATION LIMITED [GB]/[GB]
  • UNITED KINGDOM RESEARCH AND INNOVATION [GB]/[GB]
Inventors
  • RAZ, Richard
  • WOOD, Matthew
  • GODFREY, Caroline
  • MCCLOREY, Graham
  • BETTS, Corinne
  • BANERJEE, Subhashis
  • ARZUMANOV, Andrey
  • GAIT, Michael
  • VARELA, Miguel
  • HOLLAND, Ashling
Agents
  • HGF LIMITED
Priority Data
1820020.407.12.2018GB
1911405.709.08.2019GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LINKERS
(FR) LIEURS
Abstract
(EN)
The present invention relates to linkers for connecting a carrier molecule to a therapeutic molecule to form a conjugate, in particular linkers formed of amino acids such as glutamic acid, succinic acid, and gamma-aminobutyric acid. The present invention further relates to a conjugate comprising a linker of the invention, and the use of said conjugate in the treatment of various diseases.
(FR)
La présente invention concerne des lieurs pour relier une molécule porteuse à une molécule thérapeutique pour former un conjugué, en particulier des lieurs formés d'acides aminés tels que l'acide glutamique, l'acide succinique et l'acide gamma-aminobutyrique. La présente invention concerne en outre un conjugué comprenant un lieur de l'invention et l'utilisation dudit conjugué dans le traitement de diverses maladies.
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