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1. WO2020115490 - TREATMENT OF SYMPTOMS OF TRAUMATIC BRAIN INJURY

Publication Number WO/2020/115490
Publication Date 11.06.2020
International Application No. PCT/GB2019/053440
International Filing Date 05.12.2019
IPC
A61K 38/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
CPC
A61K 38/4893
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
4886Metalloendopeptidases (3.4.24), e.g. collagenase
4893Botulinum neurotoxin (3.4.24.69)
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
G01N 2333/33
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
195from bacteria
33from Clostridium (G)
G01N 2800/52
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
52Predicting or monitoring the response to treatment; Prognosis
G01N 33/9406
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
94involving narcotics ; or drugs or pharmaceuticals, neurotransmitters or associated receptors
9406Neurotransmitters
Applicants
  • IPSEN BIOPHARM LIMITED [GB]/[GB]
Inventors
  • PORRECA, Frank
  • KALINICHEV, Mikhail
Agents
  • MACLEAN, Martin Robert
Priority Data
18210573.405.12.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TREATMENT OF SYMPTOMS OF TRAUMATIC BRAIN INJURY
(FR) TRAITEMENT DE SYMPTÔMES D'UNE LÉSION CÉRÉBRALE TRAUMATIQUE
Abstract
(EN)
Method of treating or reducing a symptom of traumatic brain injury (TBI) in a subject, comprising administering to the subject a therapeutically-effective amount of botulinum neurotoxin. Composition for use in treating or reducing a symptom of TBI in a subject comprising botulinum neurotoxin. Computer system programmed to receive information related to a subject's response to administration of botulinum neurotoxin, store that response in a database, and transmit the response to a medical practitioner. Non-transitory computer-readable storage medium storing instructions that, when executed by a computer system, causes the computer system to perform the aforementioned steps.
(FR)
L'invention concerne une méthode de traitement ou de diminution d'un symptôme d'une lésion cérébrale traumatique (LCT) chez un sujet, comprenant l'administration au sujet d'une quantité thérapeutiquement efficace de neurotoxine botulique. L'invention concerne également une composition destinée à être utilisée dans le traitement ou la diminution d'un symptôme de LCT chez un sujet comprenant une neurotoxine botulique. Un système informatique est programmé pour recevoir des informations relatives à la réponse d'un sujet à l'administration de neurotoxine botulique, pour stocker cette réponse dans une base de données et pour transmettre la réponse à un médecin. Un support d'enregistrement lisible par ordinateur non transitoire qui stocke des instructions qui, lorsqu'elles sont exécutées par un système informatique, amène le système informatique à effectuer les étapes susmentionnées.
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