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1. WO2020115315 - METHOD FOR DETECTING THE PRESENCE, IDENTIFICATION AND QUANTIFICATION IN A BLOOD SAMPLE OF ANTICOAGULANTS WHICH ARE INHIBITORS OF BLOOD COAGULATION ENZYMES, AND MEANS FOR THE IMPLEMENTATION THEREOF

Publication Number WO/2020/115315
Publication Date 11.06.2020
International Application No. PCT/EP2019/084069
International Filing Date 06.12.2019
IPC
G16B 40/20 2019.01
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
40ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
20Supervised data analysis
C12Q 1/37 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
34involving hydrolase
37involving peptidase or proteinase
CPC
C12Q 1/37
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
34involving hydrolase
37involving peptidase or proteinase
G01N 2333/745
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
745Assays involving non-enzymic blood coagulation factors
G01N 2333/96444
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
90Enzymes; Proenzymes
914Hydrolases (3)
948acting on peptide bonds (3.4)
95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
964derived from animal tissue
96425from mammals
96427in general
9643with EC number
96433Serine endopeptidases (3.4.21)
96441with definite EC number
96444Factor X (3.4.21.6)
G01N 33/86
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
86involving blood coagulating time ; or factors, or their receptors
G16B 40/20
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
40ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
20Supervised data analysis
Applicants
  • DIAGNOSTICA STAGO [FR]/[FR]
Inventors
  • KERDELO, Sébastien
Agents
  • ERNEST GUTMANN & YVES PLASSERAUD SAS
Priority Data
187256207.12.2018FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) METHOD FOR DETECTING THE PRESENCE, IDENTIFICATION AND QUANTIFICATION IN A BLOOD SAMPLE OF ANTICOAGULANTS WHICH ARE INHIBITORS OF BLOOD COAGULATION ENZYMES, AND MEANS FOR THE IMPLEMENTATION THEREOF
(FR) METHODE POUR LA DETECTION DE LA PRESENCE, L'IDENTIFICATION ET LA QUANTIFICATION DANS UN ECHANTILLON SANGUIN D'ANTICOAGULANTS INHIBITEURS D'ENZYMES DE LA COAGULATION DU SANG, ET MOYENS POUR SON IMPLEMENTATION
Abstract
(EN)
The present invention relates to an in vitro method for detecting, in a biological sample, the presence of an inhibitor of a blood coagulation enzyme selected, independently, from factor Xa (FXa) and factor IIa (FIIa), the method implementing the measurement of one or more competition kinetics via the performance of a competitive enzyme assay and the implementation of one or more types of classification or regression decision models obtained by training one or more supervised machine learning models. The method may include the identification in the biological sample of a sought inhibitor, or even the characterisation or quantification (via a quantitative assay) thereof. The invention likewise relates to a data-processing system or device comprising means for implementing at least a part of the method according to the invention, a computer program or computer-readable recording medium or appropriate data, and a suitable kit.
(FR)
La présente invention concerne une méthode in vitro de détection dans un échantillon biologique, de la présence d'un inhibiteur d'une enzyme de la coagulation du sang choisie, indépendamment, parmi le facteur Xa (FXa) et le facteur IIa (FIIa), la méthode implémentant la mesure d'une ou de plusieurs cinétique(s) de compétition via la réalisation d'un dosage enzymatique compétitif et la mise en œuvre de un ou plusieurs types de modèles décisionnel de classification ou de régression obtenu(s) par entraînement de modèle(s) d'apprentissage automatique supervisé(s). La méthode peut inclure l'identification dans l'échantillon biologique d'un inhibiteur recherché, voire sa caractérisation, voire sa quantification (via un dosage quantitatif). L'invention concerne également un système de traitement de données ou dispositif comprenant des moyens pour mettre en œuvre au moins une partie de la méthode selon l'invention, un programme d'ordinateur ou support d'enregistrement lisible par ordinateur ou de données appropriés, et un kit adapté.
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