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1. WO2020115274 - COMPOSITIONS FOR IMPROVING SEXUAL FUNCTION

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[ EN ]

CLAIMS

1. A composition comprising L-arginine and L-citrulline or a physiologically acceptable salt or hydrate of any one thereof, wherein the composition is in a unit dosage form and wherein the content of L-arginine or a physiologically acceptable salt or hydrate thereof is at least 4.0 g and the content of L-citrulline or a physiologically acceptable salt or hydrate thereof is at least 1.0 g.

2. A composition according to claim 1, wherein the composition comprises one or more proanthocyanidins.

3. A composition according to claim 1 or 2, wherein the content of L-arginine or a physiologically acceptable salt or hydrate thereof is in the range of from 4.0-10.0 g.

4. A composition according to any of claims 1-3, wherein the composition is in a unit dosage form and the content of L-citrulline or a physiologically acceptable salt or hydrate thereof is in the range from 1.0-3.0 g.

5. A composition or unit dosage according to anyone of claims 1-4 for use in improving the sexual function in a sexually healthy human subject.

6. A composition or unit dosage for use according to claim 5 for use in improving sexual arousal in a sexually healthy human subject.

7. A composition or unit dosage for use according to any one of claims 5 or 6, wherein the human subject is a female.

8. A composition or unit dosage for use according to claim 7, for use in improving orgasmic function in a sexually healthy female subject.

9. A composition or unit dosage for use according to any one of claims 5 or 6, wherein the human subject is a male.

10. A composition or unit dosage for use according to claim 9, for use in improving IELT in a sexually healthy male subject.

11. A unit dosage for use according to any of claims 5-10, wherein the unit doses is administered 0.5-5.5 hours prior to sexual activity, such as 1.0-5 hours, preferably 1.0-4.5 hours, more preferably 1.0-4.0 hours, most preferably 1.0-3.5 hours, such as 1.0 - 3.0 hours prior to sexual activity.

12. Use of a pharmaceutical composition or unit dosage according to anyone of claims 1-4 for improving sexuality and/or sexual function of a healthy human subject for a time period of up to 6 hours.

13. A method of improving sexuality and/or sexual function of a healthy human subject for a time period of up to 6 hours comprising the steps of administering one or more unit dosages according to any one of claims 1-4 to the subject.

14. A pharmaceutical composition or unit dosage according to anyone of claims 1-4 for use as a medicament.

15. A pharmaceutical composition or unit dosage according to anyone of claims 1-4, for use in the treatment of a sexual disorder or dysfunction in a human subject, wherein the sexual disorder or dysfunction is selected from the group consisting of endothelial dysfunction, erectile dysfunction, impotence, sexual arousal disorder, hypoactive sexual desire disorder (HSDD), sexual aversion disorder (SAD), orgasmic disorder (anorgasmia), premature ejaculation, dyspareunia, vaginismus and/or sexual dissatisfaction (non-specific).