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1. WO2020115254 - COLONIC DRUG DELIVERY FORMULATION

Publication Number WO/2020/115254
Publication Date 11.06.2020
International Application No. PCT/EP2019/083909
International Filing Date 05.12.2019
IPC
A61K 9/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
28Dragees; Coated pills or tablets
CPC
A61K 9/2846
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
28Dragees; Coated pills or tablets ; , e.g. with film or compression coating
2806Coating materials
2833Organic macromolecular compounds
284obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
2846Poly(meth)acrylates
A61K 9/2853
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
28Dragees; Coated pills or tablets ; , e.g. with film or compression coating
2806Coating materials
2833Organic macromolecular compounds
2853obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
A61K 9/2866
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
28Dragees; Coated pills or tablets ; , e.g. with film or compression coating
2806Coating materials
2833Organic macromolecular compounds
286Polysaccharides, e.g. gums; Cyclodextrin
2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
A61K 9/2886
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
28Dragees; Coated pills or tablets ; , e.g. with film or compression coating
2886having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
Applicants
  • TILLOTTS PHARMA AG [CH]/[CH]
Inventors
  • VARUM, Felipe
  • BRAVO GONZÁLEZ, Roberto Carlos
Agents
  • BECK GREENER LLP
Priority Data
18211154.207.12.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COLONIC DRUG DELIVERY FORMULATION
(FR) FORMULATION D’ADMINISTRATION DE MÉDICAMENT AU CÔLON
Abstract
(EN)
A delayed release drug formulation for oral administration to deliver a drug to the colon of a subject. The formulation comprises a core comprising and drug and coating for the core. The coating comprises an outer layer and an inner layer. The outer layer comprises a film- forming enteric polymer having a pH threshold at about pH 6 or above and the inner layer comprises a film-forming non-ionic polymer that is soluble in intestinal or gastrointestinal fluid, and a buffer agent in an amount from more than 20 wt % to about 60 wt %, based on the dry weight of the non-ionic polymer.
(FR)
La présente invention concerne une formulation de médicament à libération retardée pour l’administration par voie orale pour administrer un médicament au côlon d’un sujet. La formulation comprend un cœur comprenant un médicament et le revêtement du cœur. Le revêtement comprend une couche externe et une couche interne. La couche externe comprend un polymère entérique formant film ayant un seuil de pH d’environ le pH 6 ou supérieur et la couche interne comprend un polymère non ionique formant film qui est soluble dans le liquide intestinal ou gastro-intestinal, et un agent tampon en une quantité de plus de 20 % en pds à environ 60 % en pds, sur la base du poids sec du polymère non ionique.
Also published as
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