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1. WO2020115178 - MICROFLUIDIC DEVICES

Publication Number WO/2020/115178
Publication Date 11.06.2020
International Application No. PCT/EP2019/083758
International Filing Date 04.12.2019
IPC
B01F 13/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
13Other mixers; Mixing plant, including combinations of dissimilar mixers
B01F 5/06 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
5Flow mixers; Mixers for falling materials, e.g. solid particles
06Mixers in which the components are pressed together through slits, orifices, or screens
B01F 3/08 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
3Mixing, e.g. dispersing, emulsifying, according to the phases to be mixed
08liquids with liquids; Emulsifying
CPC
B01F 13/0064
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
13Other mixers; Mixing plant, including combinations of ; mixers, e.g. of; dissimilar mixers
0059Micromixers
0061using specific means for arranging the streams to be mixed
0064Mixing chamber
B01F 2215/0431
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
2215Auxiliary or complementary information in relation with mixing
04Technical information in relation with mixing
0413Numerical information
0418Geometrical information
0431Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
B01F 3/0807
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
3Mixing, e.g. dispersing, emulsifying, according to the phases to be mixed
08liquids with liquids; Emulsifying
0807Emulsifying
B01F 5/0651
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
5Flow mixers
06Mixers in which the components are pressed together through slits, orifices, or screens; ; Static mixers; Mixers of the fractal type
0602Static mixers, i.e. mixers in which the mixing is effected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
0609Mixing tubes, e.g. the material being submitted to a substantially radial movement or to a movement partially in reverse direction
0646Mixers composed of several consecutive mixing tubes; Mixing tubes being deformed or bent, e.g. having varying cross-section or being provided with inwardly extending profiles, e.g. with internal screw-thread profile
0651Mixers with a converging cross-section
Applicants
  • GLAXOSMITHKLINE BIOLOGICALS SA [BE]/[BE]
Inventors
  • BUESINK, Wilfred
  • JEHOULET, Philippe
  • MENAFRO, Amedeo
  • STRODIOT, Laurent Bernard Jean
  • TOMBA, Emanuele
Agents
  • EVANS, Stephen
Priority Data
18210865.406.12.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MICROFLUIDIC DEVICES
(FR) DISPOSITIFS MICROFLUIDIQUES
Abstract
(EN)
The present invention relates broadly to microfluidic devices, particularly microfluidic devices optimised for the industrial production of nanoparticles such as liposomes. The device (101) comprises a substrate which extends between a distal end (107) comprising an outlet region (105) and a proximal end (108) comprising an inlet region (106). The inlet region comprises two substantially parallel outer channels (103a, 103b) for transport of a first fluid, said outer channels (103a, 103b) defined in part by a first outer wall (109a) and a second outer wall (109b) respectively, and a linear inner channel (104) for transport of a second fluid. The linear channel is disposed between the two substantially parallel outer channels. The outer channels (103a, 103b) and inner channel (104) extend from the proximal end (108) to a mixing chamber (102) which extends from the inlet region (106) to the outlet region (105). The mixing chamber (102) is in flow communication with the inner and outer channels (103a, 103b, 104) to receive the first and second fluids from the inner and outer channels (103a, 103b, 104) and the mixing chamber (102) has a uniform width (W) along its length substantially equal to the width (W1) between the outer walls (109a, 109b) of the two substantially parallel outer channels (103a, 103b).
(FR)
La présente invention concerne de manière générale des dispositifs microfluidiques, en particulier des dispositifs microfluidiques optimisés pour la production industrielle de nanoparticules telles que des liposomes.
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