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1. WO2020115113 - DUAL AGONIST GLP-1 AND NEUROTENSIN FUSION PEPTIDE

Publication Number WO/2020/115113
Publication Date 11.06.2020
International Application No. PCT/EP2019/083634
International Filing Date 04.12.2019
IPC
C07K 14/605 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
605Glucagons
C07K 7/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
C12N 15/62 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
C07K 14/575 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
C07K 7/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
22Eledoisins; Related peptides
CPC
C07K 14/575
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
C07K 14/605
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
605Glucagons
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
C07K 2319/74
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
70containing domain for protein-protein interaction
74containing a fusion for binding to a cell surface receptor
C07K 2319/75
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
70containing domain for protein-protein interaction
74containing a fusion for binding to a cell surface receptor
75containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
C07K 7/083
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
083Neurotensin
Applicants
  • KØBENHAVNS UNIVERSITET [DK]/[DK]
Inventors
  • HOLST, Birgitte
  • RATNER, Cecilia
Agents
  • AWA DENMARK A/S
Priority Data
18210211.104.12.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DUAL AGONIST GLP-1 AND NEUROTENSIN FUSION PEPTIDE
(FR) PEPTIDE DE FUSION DE GLP-1 ET DE NEUROTENSINE À DOUBLE EFFET AGONISTE
Abstract
(EN)
The present invention relates to a polypeptide comprising a first peptide linked to a second peptide, optionally via a linker molecule, which first peptide comprises an appetite regulating hormone peptide, e.g. glucagon like peptide 1 (GLP-1), such as amino acids 7-37 of the initial GLP-1 product (1–37), and a Neurotensin (NT) like peptide, targeting both the GLP-1 receptor (GLP-1R) and NT receptors (NTR1-3) and display an increased effect on decrease of appetite and food intake and body weight compared to simultaneous administration of both peptides.
(FR)
La présente invention concerne un polypeptide comprenant un premier peptide lié à un second peptide, éventuellement par l'intermédiaire d'une molécule de liaison, lequel premier peptide comprend un peptide d'hormone de régulation de l'appétit, par exemple un peptide de type glucagon 1 (GLP-1), tel que des acides aminés 7-37 du produit de GLP-1 initial (1–37), et un peptide de type neurotensine (NT), ciblant à la fois le récepteur GLP-1 (GLP-1R) et les récepteurs NT (NTR1-3) et affichant un effet accru sur la diminution de l'appétit, de la prise alimentaire et du poids corporel par rapport à l'administration simultanée des deux peptides.
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