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1. WO2020115019 - KCHIP2 MODULATOR COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CARDIOVASCULAR DISEASES

Publication Number WO/2020/115019
Publication Date 11.06.2020
International Application No. PCT/EP2019/083432
International Filing Date 03.12.2019
IPC
A61K 31/4412 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4412having oxo groups directly attached to the heterocyclic ring
A61P 9/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
CPC
A61K 31/4412
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4412having oxo groups directly attached to the heterocyclic ring
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants
  • CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) [ES]/[ES]
  • UNIVERSIDAD AUTÓNOMA DE MADRID [ES]/[ES]
Inventors
  • GUTIERREZ RODRIGUEZ, Marta
  • VALENZUELA MIRANDA, Carmen
  • MARTIN MARTINEZ, Mercedes
  • DELGADO CANENCIA, Carmen
  • NARANJO OROVIO, Jose Ramón
Agents
  • PONS ARIÑO, Angel
Priority Data
18382890.404.12.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) KCHIP2 MODULATOR COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
(FR) COMPOSÉS MODULATEURS DE KCHIP2 ET LEUR UTILISATION POUR LE TRAITEMENT DE MALADIES CARDIOVASCULAIRES
Abstract
(EN)
The present invention relates to a family of compounds which are capable of modulating KChIP proteins and are therefore useful for the treatment of heart diseases in which the expression levels of this protein are abnormal. These compounds have the following general formula: (I).
(FR)
La présente invention concerne une famille de composés qui sont capables de moduler les protéines KChIP et qui sont par conséquent utiles pour le traitement de maladies cardiaques dans lesquelles les niveaux d'expression de cette protéine sont anormaux. Ces composés ont la formule générale suivante : (I).
Latest bibliographic data on file with the International Bureau