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International application No. Applicant's or agent's file reference
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
02 December 2019 03 December 2018
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
none of the figures is to be published with the abstract.


     C07D 403/14 (2006.01)i; C07D 401/12 (2006.01)i; C07D 409/14 (2006.01)i; A61P 35/00 (2006.01)i; A61P 37/00 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC


Minimum documentation searched (classification system followed by classification symbols):
     C07D; A61P
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, CHEM ABS Data, WPI Data


Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
WO 2018011681 A1 (PFIZER [US]) 18 January 2018 (2018-01-18)
page 20, line 6 - page 22, line 28; page 23, general Formula Ia; pages 68-70, Schemes 3, 4, 5 and 6; examples, e.g. Examples 7, 10, 23, 36, 193, 196; pages 175-181, "Summury of Biological Assays and Data"
WO 2016193844 A1 (PFIZER [US]) 08 December 2016 (2016-12-08)
page 17, lines 25-29; page 21, line 18 - page 22, line 13, whereby W is selected from (i) and G2 is a hydrogen atom; page 27, lines 9-10; page 89, Scheme 1, compound XV; examples, e.g. Examples 1, 12, 19, 139, 140, 144; pages 166-172, Table 1
Special categories of cited documents:
document defining the general state of the art which is not considered to be of particular relevance
document cited by the applicant in the international application
earlier application or patent but published on or after the international filing date
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
document referring to an oral disclosure, use, exhibition or other means
document published prior to the international filing date but later than the priority date claimed
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
document member of the same patent family


Patent document cited in search report Publication date
Patent family member(s) Publication date
WO 2018011681 A1
18 January 2018
AU 2017296338 A1
BR 112019000589 A2
CA 3030381 A1
CN 109476645 A
EP 3484876 A1
JP 2019524716 A
KR 20190026902 A
SG 11201811161Y A
US 2019315715 A1
WO 2018011681 A1
03 January 2019
24 April 2019
18 January 2018
15 March 2019
22 May 2019
05 September 2019
13 March 2019
30 January 2019
17 October 2019
18 January 2018
WO 2016193844 A1
08 December 2016
CA 2987179 A1
EP 3303303 A1
JP 2018516254 A
US 2018148420 A1
US 2019292157 A1
WO 2016193844 A1
08 December 2016
11 April 2018
21 June 2018
31 May 2018
26 September 2019
08 December 2016
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
18 February 2020
Date of mailing of the international search report:
05 March 2020
Authorized officer:
Sen, Alina
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