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1. WO2020114905 - PROCESS FOR PREPARING GLYCOLIDE

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[ EN ]

CLAIMS

1. A process for producing glycolide comprising an oxidation step of contacting glycolaldehyde dimer with an oxidizing agent to produce a glycolide product.

2. The process according to claim 1, wherein the oxidation step is carried out in an aprotic solvent.

3. The process according to claim 2, wherein the oxidation step is carried out in a reaction mixture comprising the glycolaldehyde dimer, the oxidizing agent, the glycolide product and the aprotic solvent.

4. The process according to claim 3, wherein the aprotic solvent makes up at least 70 wt%, such as at least 80, 90 or 95 wt% of the reaction mixture.

5. The process according to any one of claims 2 to 4, wherein the aprotic solvent is an oxo- compound.

6. The process according to any one of claims 2 to 5, wherein the aprotic solvent is selected from the group consisting of N-methylpyrrolidone, dichloromethane, tetrahydrofuran (THF), ethyl acetate (EtOAc), acetone, methyl ethyl ketone, methyl isobutyl ketone, N, N- dimethylformamide (DMF), acetonitrile (MeCN), dimethyl sulfoxide (DMSO), propylene carbonate (PC), dioxane, and cyclohexanone; or mixtures thereof.

7. The process according to any one of the preceding claims, wherein the glycolaldehyde dimer is biobased.

8. The process according to any one of the preceding claims, wherein the oxidizing agent is selected from the group consisting of Dess-Martin periodinane, peracetic acid, oxygen, hydrogen peroxide, Oppenauer oxidation catalyst, metallo silicates, Shvo's catalyst, and aluminum isopropoxide; or mixtures thereof.

9. The process according to any one of the preceding claims, wherein the oxidation step is conducted at a temperature in the range of from 0-100 °C, such as in the range of from 20-80 or 30-60 °C.

10. The process according to any one of the preceding claims, wherein the oxidation step is conducted as a continuous process.

11. The process according to any one of claims 3 to 10, wherein the reaction mixture has a pH which is kept in the range of from 6 to 8.

12. The process according to any one of the preceding claims, wherein the glycolide is recovered.