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1. WO2020114893 - CRISPR GUIDE-RNA EXPRESSION STRATEGIES FOR MULTIPLEX GENOME ENGINEERING


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2019/083018 33292-WO-PCT
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
29 November 2019 05 December 2018
Applicant
DSM IP ASSETS B.V.
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C12N 15/113 (2010.01)i; C12N 15/85 (2006.01)i; C12N 15/10 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C12N
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, BIOSIS, EMBASE, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
WO 2015153940 A1 (MASSACHUSETTS INST TECHNOLOGY [US]) 08 October 2015 (2015-10-08)
1-15
the whole document
(2)
Y
WO 2017037304 A2 (DSM IP ASSETS BV [NL]) 09 March 2017 (2017-03-09)
1-15
cited in the application
the whole document
(3)
Y
RENÉ VERWAAL ET AL, "CRISPR/Cpf1 enables fast and simple genome editing of Saccharomyces cerevisiae", YEAST,Vol. 35, No. 2, 12 November 2017 (2017-11-12), page 201-211,
XP055592406
1-15
the whole document
(4)
A
D. G. GIBSON, "Synthesis of DNA fragments in yeast by one-step assembly of overlapping oligonucleotides", NUCLEIC ACIDS RESEARCH,Vol. 37, No. 20, 01 November 2009 (2009-11-01), page 6984-6990,
XP055343126
1-15
cited in the application
the whole document
(5)
A
OWEN W RYAN ET AL, "Selection of chromosomal DNA libraries using a multiplex CRISPR system", ELIFE,Vol. 3, 19 August 2014 (2014-08-19), page 1-15,
XP055175718
1-15
the whole document
(6)
A
OWEN W RYAN* ET AL, "Multiplex Engineering of Industrial Yeast Genomes Using CRISPRm", METHODS IN ENZYMOLOGY,Vol. 546, 2014, page 473-489,
XP009183140
1-15
the whole document
(7)
A
WO 2015099850 A1 (GEN HOSPITAL CORP [US]) 02 July 2015 (2015-07-02)
1-15
the whole document
(8)
A
WO 2016061481 A1 (PENN STATE RES FOUND [US]) 21 April 2016 (2016-04-21)
1-15
the whole document
(9)
A
WO 2016110453 A1 (DSM IP ASSETS BV [NL]; UNIV GRONINGEN [NL]) 14 July 2016 (2016-07-14)
1-15
the whole document
(10)
T
KLAUDIA CIURKOT ET AL, "CRISPR/Cas12a Multiplex Genome Editing of Saccharomyces cerevisiae and the Creation of Yeast Pixel Art", JOURNAL OF VISUALIZED EXPERIMENTS,Vol. 147, May 2019 (2019-05), page 1-15,
XP055667175
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2015153940 A1
08 October 2015
CN 106170550 A
EP 3126503 A1
JP 2017509350 A
US 2017022499 A1
WO 2015153940 A1
30 November 2016
08 February 2017
06 April 2017
26 January 2017
08 October 2015
WO 2017037304 A2
09 March 2017
CN 109563505 A
EP 3491130 A2
US 2019185843 A1
WO 2017037304 A2
02 April 2019
05 June 2019
20 June 2019
09 March 2017
WO 2015099850 A1
02 July 2015
AU 2014370416 A1
CA 2935032 A1
CN 106103706 A
EP 3090044 A1
JP 2017505117 A
KR 20160102056 A
WO 2015099850 A1
07 July 2016
02 July 2015
09 November 2016
09 November 2016
16 February 2017
26 August 2016
02 July 2015
WO 2016061481 A1
21 April 2016
BR 112017007923 A2
CA 2964796 A1
CN 107027313 A
EP 3207139 A1
US 2016264981 A1
US 2019330647 A1
WO 2016061481 A1
20 March 2018
21 April 2016
08 August 2017
23 August 2017
15 September 2016
31 October 2019
21 April 2016
WO 2016110453 A1
14 July 2016
EP 3242950 A1
WO 2016110453 A1
15 November 2017
14 July 2016
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
11 February 2020
Date of mailing of the international search report:
20 February 2020
Authorized officer:
Andres, Serge
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