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1. WO2020114616 - TOPICAL TREATMENT OF IMMUNE CHECKPOINT INHIBITOR INDUCED DIARRHOEA, COLITIS OR ENTEROCOLITIS USING ANTIBODIES AND FRAGMENTS THEREOF


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2018/084057 PWO00320TIL
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
07 December 2018
Applicant
TILLOTTS PHARMA AG
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C07K 16/24 (2006.01)i; A61K 39/00 (2006.01)i; A61K 9/00 (2006.01)i; A61K 9/14 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C07K; A61K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, BIOSIS

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
US 2010003249 A1 (SILENCE KAREN [BE] ET AL) 07 January 2010 (2010-01-07)
1-25
abstract; figures 2, 3; examples 4-7; table 7; sequences SEQ ID NOs: 12 - 13
page 9, paragraph [0165] - page 10, paragraph [0167]
page 16, paragraph [0253] - paragraph [0256]
page 17, paragraph [0258] - paragraph [0265]
page 20, line [0330] - page 21, line [0335]
(2)
X
RANDALL BURTON ET AL, "Tu1283 Proteolytic Stability of AVX-470, a Bovine Colostral Anti-TNF Antibody, Determined In Vitro and in Clinical Samples After Oral Administration to Patients With Ulcerative Colitis", GASTROENTEROLOGY : OFFICIAL PUBLICATION OF THE AMERICAN GASTROENTEROLOGICAL ASSOCIATION,Vol. 148, No. 4, 01 April 2015 (2015-04-01), page S-847,
XP055611284
1-25
the whole document
(3)
A
MABUS JOHN ET AL, "Enteric-coated capsule intestinal delivery of human immunoglobulin G in cynomolgus macaques", FASEB JOURNAL,Vol. 28, No. 1, Suppl. S, April 2014 (2014-04), page LB603,
XP009515098
16-25
the whole document
(4)
T
YADAV VIPUL ET AL, "Gastrointestinal stability of therapeutic anti-TNF [alpha] IgG1 monoclonal antibodies", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER, NL,Vol. 502, No. 1, 15 February 2016 (2016-02-15), page 181-187,
XP029449399
abstract; figures 1-7; tables 1, 2
page 182 - page 187
(5)
T
BOHUI XU ET AL, "Eudragit L100-coated mannosylated chitosan nanoparticles for oral protein vaccine delivery", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.,Vol. 113, 01 July 2018 (2018-07-01), page 534-542,
XP055611302
abstract
(6)
T
PREISIG DANIEL ET AL, "Mucoadhesive microparticles for local treatment of gastrointestinal diseases", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL,Vol. 105, 11 June 2016 (2016-06-11), page 156-165,
XP029627741
abstract
(7)
T
SOM ANIRUDDH ET AL, "Immune checkpoint inhibitor-induced colitis: A comprehensive review", WORLD JOURNAL OF CLINICAL CASES,,Vol. 7, No. 4, 26 February 2019 (2019-02-26), page 405-418,
XP009515083
abstract; tables 1-3
page 406
page 411 - page 414
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
US 2010003249 A1
07 January 2010
AU 2010226938 A1
CA 2505316 A1
CA 2505325 A1
CA 2505326 A1
EP 1900753 A2
EP 2258392 A1
EP 2284192 A2
EP 2301967 A2
EP 2316852 A1
EP 2336179 A1
EP 2390268 A1
EP 3299393 A1
HK 1082745 A1
IL 168357 A
JP 2006519763 A
JP 2006520584 A
JP 2006524036 A
JP 2011024581 A
JP 2011256169 A
MX PA05004955 A
NZ 540194 A
NZ 540195 A
NZ 540196 A
NZ 563471 A
RU 2012108416 A
US 2006115470 A1
US 2009324512 A1
US 2010003248 A1
US 2010003249 A1
US 2010021459 A1
US 2010040613 A1
US 2011184145 A1
WO 2004041862 A2
WO 2004041863 A2
WO 2004041865 A2
28 October 2010
21 May 2004
21 May 2004
21 May 2004
19 March 2008
08 December 2010
16 February 2011
30 March 2011
04 May 2011
22 June 2011
30 November 2011
28 March 2018
22 April 2016
27 September 2011
31 August 2006
14 September 2006
26 October 2006
10 February 2011
22 December 2011
17 November 2005
31 July 2008
31 January 2009
26 September 2008
30 April 2009
10 September 2013
01 June 2006
31 December 2009
07 January 2010
07 January 2010
28 January 2010
18 February 2010
28 July 2011
21 May 2004
21 May 2004
21 May 2004
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
07 August 2019
Date of mailing of the international search report:
16 August 2019
Authorized officer:
Schulz, Regine
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