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1. WO2020114583 - A METHOD OF MODULATING HIV-1 PROVIRUS ACTIVATION AND REPLICATION

Publication Number WO/2020/114583
Publication Date 11.06.2020
International Application No. PCT/EP2018/083549
International Filing Date 04.12.2018
IPC
A61P 31/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
A61K 31/495 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
CPC
A61K 31/495
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
Applicants
  • CHEMESTMED LTD. [EE]/[EE]
Inventors
  • SELBERG, Simona
  • ŽUSINAITE, Eva
  • MERITS, Andre
  • KARELSON, Mati
Agents
  • SARAP, Margus
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A METHOD OF MODULATING HIV-1 PROVIRUS ACTIVATION AND REPLICATION
(FR) PROCÉDÉ DE MODULATION DE L'ACTIVATION ET DE LA RÉPLICATION DU PROVIRUS DU VIH-1
Abstract
(EN)
Methods and compounds are reported that specifically modulate HIV-1 provirus activation and replication of emerged virus genome by activation of the RNA methyltransferase complex METTL3/METTL14. In some embodiments, the compound has binding and/or activation for a METTL3/METTL14/WTAP complex.
(FR)
L'invention concerne des procédés et des composés qui modulent spécifiquement l'activation et la réplication du provirus du VIH-1 d'un génome de virus émergent par activation du complexe de méthyltransferase d'ARN METTL3/METTL14. Dans certains modes de réalisation, le composé se lie au complexe METTL3/METTL14/WTAP et/ou active ce dernier.
Latest bibliographic data on file with the International Bureau