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1. WO2020114514 - CRYSTALLINE FORM OF PROPANAMIDE DERIVATIVE AND PREPARATION METHOD THEREFOR

Publication Number WO/2020/114514
Publication Date 11.06.2020
International Application No. PCT/CN2019/123939
International Filing Date 09.12.2019
IPC
C07D 413/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
C07D 217/24 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
22with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
24Oxygen atoms
C07D 401/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
A61K 31/4725 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
472Non-condensed isoquinolines, e.g. papaverine
4725containing further heterocyclic rings
A61P 25/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Applicants
  • 江苏恩华药业股份有限公司 NHWA PHARMA. CORPORATION [CN]/[CN]
Inventors
  • 郝超 HAO, Chao
Agents
  • 北京永新同创知识产权代理有限公司 NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD.
Priority Data
201811499965.407.12.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CRYSTALLINE FORM OF PROPANAMIDE DERIVATIVE AND PREPARATION METHOD THEREFOR
(FR) FORME CRISTALLINE D'UN DÉRIVÉ DE PROPANAMIDE ET PROCÉDÉ DE PRÉPARATION CORRESPONDANT
(ZH) 一种丙酰胺类衍生物的结晶形式及其制备方法
Abstract
(EN)
The present invention relates to crystal form A of a propanamide derivative and a preparation method therefor. The crystal form A of the compound of formula (1) obtained in the present invention has good crystalline stability and chemical stability, and can be better used in clinical treatment.
(FR)
La présente invention concerne une forme cristalline A d'un dérivé de propanamide et un procédé de préparation correspondant. La forme cristalline A du composé de formule (1) fournie par la présente invention présente une bonne stabilité cristalline et une bonne stabilité chimique, et peut être mieux utilisée dans un traitement clinique.
(ZH)
本发明涉及一种丙酰胺类衍生物的A晶型及其制备方法,本发明所得到的式(1)化合物的A晶型具有良好的晶型稳定性和化学稳定性,可更好地用于临床治疗。
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