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1. WO2020114499 - TYROSINE KINASE INHIBITORS, COMPOSITIONS AND METHODS THERE OF

Publication Number WO/2020/114499
Publication Date 11.06.2020
International Application No. PCT/CN2019/123719
International Filing Date 06.12.2019
IPC
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/519 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • BETTA PHARMACEUTICALS CO., LTD [CN]/[CN]
Inventors
  • FU, Bang
  • LI, Yinlong
  • REN, Wei
  • CHEN, Jie
  • LIU, Xiangyong
  • WANG, Jiabing
  • DING, Lieming
Priority Data
PCT/CN2018/11989507.12.2018CN
PCT/CN2019/08620409.05.2019CN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TYROSINE KINASE INHIBITORS, COMPOSITIONS AND METHODS THERE OF
(FR) INHIBITEURS DE TYROSINE KINASE, COMPOSITIONS ET PROCÉDÉS ASSOCIÉS
Abstract
(EN)
The present invention relates to compounds of Formula (I), methods of using the compounds as Trk inhibitors, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections. (I)
(FR)
L'invention concerne des composés de formule I, des procédés d'utilisation des composés en tant qu'inhibiteurs de Trk, et des compositions pharmaceutiques comprenant de tels composés. Les composés sont utiles dans le traitement, la prévention ou l’atténuation de maladies ou de troubles tels que le cancer ou les infections.
Latest bibliographic data on file with the International Bureau