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1. WO2020114495 - DINUCLEOTIDE COMPOUND AND PRODRUG THEREOF

Publication Number WO/2020/114495
Publication Date 11.06.2020
International Application No. PCT/CN2019/123704
International Filing Date 06.12.2019
IPC
A61K 31/7084 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7084Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
C07H 21/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
A61P 31/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
A61P 1/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
CPC
A61K 31/7084
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7084Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 31/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
C07H 21/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
Applicants
  • 正大天晴药业集团股份有限公司 CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. [CN]/[CN]
Inventors
  • 张寅生 ZHANG, Yinsheng
  • 刘保民 LIU, Baomin
  • 朱炎 ZHU, Yan
  • 盖阔 GAI, Kuo
  • 黄雨 HUANG, Yu
  • 尧超 YAO, Chao
  • 童顺禹 TONG, Shunyu
  • 张洋 ZHANG, Yang
  • 王晓金 WANG, Xiaojin
Agents
  • 北京英赛嘉华知识产权代理有限责任公司 INSIGHT INTELLECTUAL PROPERTY LIMITED
Priority Data
201811487263.406.12.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) DINUCLEOTIDE COMPOUND AND PRODRUG THEREOF
(FR) COMPOSÉ DE DINUCLÉOTIDE ET PROMÉDICAMENT DE CELUI-CI
(ZH) 二核苷酸化合物及其前体药物
Abstract
(EN)
Disclosed are a dinucleotide compound and a prodrug thereof. Specifically, disclosed are a dinucleotide compound represented by general formula (I), a tautomer, stereoisomer, or pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition thereof, and medical use thereof in treating hepatitis B virus infection, in particular, hepatic diseases resulting from hepatitis B virus infection.
(FR)
L'invention concerne un composé de dinucléotide et un promédicament de ce dernier. De façon spécifique, l'invention concerne un composé de dinucléotide représenté par la formule générale (I), un tautomère, un stéréoisomère ou un sel pharmaceutiquement acceptable de celui-ci, un procédé de préparation associé, une composition pharmaceutique de celui-ci, et son utilisation médicale dans le traitement d'une infection provoquée par le virus de l'hépatite B, en particulier, des maladies hépatiques résultant d'une infection par le virus de l'hépatite B.
(ZH)
公开了二核苷酸化合物及其前体药物。具体而言,公开了通式(I)所示的二核苷酸化合物、其互变异构体、立体异构体或其药学上可接受的盐、其制备方法、其药物组合物及其在治疗乙型肝炎病毒感染,尤其是乙型肝炎病毒感染引起的肝脏疾病中的医药用途。
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