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1. WO2020114480 - ANTI-CLAUDIN ANTIBODIES AND USES THEREOF

Publication Number WO/2020/114480
Publication Date 11.06.2020
International Application No. PCT/CN2019/123588
International Filing Date 06.12.2019
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • ZAI LAB (SHANGHAI) CO., LTD. [CN]/[CN] (CN)
  • ZLIP HOLDING LIMITED (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CO, CR, CU, CY, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW)
Inventors
  • LI, Yong
  • SHAN, Fengli
  • FANG, Xu
  • DAI, Xinchuan
  • LI, Shou
  • LI, Hong
  • LIN, Yuan
  • QI, Shali
  • JIANG, Yuejing
  • LI, Jing
  • WAN, Bing
  • YAN, James
  • SU, Yunpeng
  • FANTIN, Valeria Rosa
Agents
  • AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE
Priority Data
PCT/CN2018/11979707.12.2018CN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-CLAUDIN ANTIBODIES AND USES THEREOF
(FR) ANTICORPS ANTI-CLAUDINE ET LEURS UTILISATIONS
Abstract
(EN)
Disclosed herein are anti-Claudin 18.2 antibodies and pharmaceutical compositions comprising the same. In some embodiments, also described herein are methods of treating a subject having a cancer with an anti-Claudin 18.2 antibody and methods of inducing cell kill effect with an anti-Claudin 18.2 antibody.
(FR)
L'invention concerne des anticorps anti-claudine 18.2 et des compositions pharmaceutiques les comprenant. Dans certains modes de réalisation, l'invention concerne également des méthodes de traitement d'un sujet atteint d'un cancer à l'aide d'un anticorps anti-claudine 18.2 et des procédés permettant d'induire un effet de destruction cellulaire avec un anticorps anti-claudine 18.2.
Latest bibliographic data on file with the International Bureau