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1. WO2020114465 - PREPARATION AND APPLICATION OF HETEROAROMATIC IMINAZOLE COMPOUND

Publication Number WO/2020/114465
Publication Date 11.06.2020
International Application No. PCT/CN2019/123407
International Filing Date 05.12.2019
IPC
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14containing three or more hetero rings
C07D 405/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
C07D 413/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
C07D 417/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
Applicants
  • 上海轶诺药业有限公司 SHANGHAI ENNOVABIO PHARMACEUTICALS CO., LTD. [CN]/[CN]
Inventors
  • 江磊 JIANG, Lei
  • 冯志勇 FENG, Zhiyong
  • 金贤 JIN, Xian
  • 乔智 QIAO, Zhi
  • 尚珂 SHANG, Ke
  • 寿建勇 SHOU, Jianyong
  • 吴淡宜 WU, Danyi
  • 许灵灵 XU, Lingling
  • 徐圆 XU, Yuan
  • 张淑芸 ZHANG, Shuyun
  • 张毅 ZHANG, Yi
  • 张宇星 ZHANG, Yuxing
  • 郑明伟 ZHENG, Mingwei
Agents
  • 上海一平知识产权代理有限公司 XU & PARTNERS, LLC.
Priority Data
201811481061.905.12.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) PREPARATION AND APPLICATION OF HETEROAROMATIC IMINAZOLE COMPOUND
(FR) PRÉPARATION ET UTILISATION D'UN COMPOSÉ D'IMINAZOLE HÉTÉROAROMATIQUE
(ZH) 一类咪唑并芳环类化合物的制备和应用
Abstract
(EN)
Provided are the preparation and application of an aromatic amide compound. Specifically, provided is a compound represented by the following formula I, the definition of each group being as described in the description. The compound has TRK kinase inhibitory activity and may be used as a pharmaceutical composition for treating TRK dysfunction-related diseases.
(FR)
L'invention concerne la préparation et l'utilisation d'un composé amide aromatique. La présente invention concerne particulièrement, un composé tel que représenté par la formule suivante (I), la définition de chaque groupe étant telle que décrite dans la description. Le composé a une activité inhibitrice de la kinase TRK et peut être utilisé comme composition pharmaceutique pour le traitement de maladies liées à un dysfonctionnement de TRK.
(ZH)
提供了一类芳香酰胺化合物的制备和应用,具体地,提供了一种如下式I所示的化合物,其中,各基团的定义如说明书中所述。所述的化合物具有TRK激酶抑制活性,可以作为治疗TRK功能异常相关疾病的药物组合物。
Also published as
Latest bibliographic data on file with the International Bureau