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1. WO2020114457 - N-ACYL SULFONAMIDE SALT FBPASE INHIBITOR, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF

Publication Number WO/2020/114457
Publication Date 11.06.2020
International Application No. PCT/CN2019/123301
International Filing Date 05.12.2019
IPC
C07D 209/42 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
30with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
A61K 31/404 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
A61P 3/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 3/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 27/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
A61P 13/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
Applicants
  • 中国医学科学院药物研究所 INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES [CN]/[CN]
Inventors
  • 徐柏玲 XU, Bailing
  • 申竹芳 SHEN, Zhufang
  • 周洁 ZHOU, Jie
  • 刘率男 LIU, Shuainan
  • 别建波 BIE, Jianbo
  • 李燕 LI, Yan
  • 李荣翠 LI, Rongcui
  • 崔国楠 CUI, Guonan
  • 扈金萍 HU, Jinping
  • 盛莉 SHENG, Li
  • 孙淑娟 SUN, Shujuan
Agents
  • 北京尚诚知识产权代理有限公司 SHANGCHENG & PARTNERS
Priority Data
201811481436.105.12.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) N-ACYL SULFONAMIDE SALT FBPASE INHIBITOR, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF
(FR) INHIBITEUR DE FBPASE DE SEL N-ACYL SULFONAMIDE, SON PROCÉDÉ DE PRÉPARATION, SA COMPOSITION PHARMACEUTIQUE ET SES APPLICATIONS
(ZH) N-酰基磺酰胺盐类FBPase抑制剂、其制备方法、药物组合物及用途
Abstract
(EN)
Provided herein are a compound acting as FBPase inhibitor, and particularly an N-acyl sulfonamide salt FBPase compound of formula I. Further provided herein are a method for preparing the compound of formula I, one or more compositions made thereof, the compound acting as a drug for treating FBPase-related diseases, and uses of the compound in preparing a drug for preventing and/or treating diabetes.
(FR)
L'invention concerne un composé tenant lieu d'inhibiteur de FBPase et, plus particulièrement, un composé FBPase de formule I. L'invention concerne en outre un procédé de préparation dudit composé de formule I, une ou plusieurs compositions obtenues à partir de celui-ci, le composé agissant comme médicament pour le traitement de maladies associées à la FBPase et les applications dudit composé dans la préparation d'un médicament pour la prévention et/ou le traitement du diabète.
(ZH)
本申请公开了作为FBPase抑制剂的化合物,具体为式I所示的N-酰基磺酰胺盐类化合物。本申请还公开了式I化合物的制备方法,含有一个或多个该类化合物的组合物,以及所述化合物作为药物,治疗与FBPase有关的疾病,及在制备预防和/或治疗糖尿病的药物中的用途。
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