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1. WO2020114399 - CD47 ANTIBODY, PREPARATION METHOD THEREFOR AND USES THEREOF

Publication Number WO/2020/114399
Publication Date 11.06.2020
International Application No. PCT/CN2019/122777
International Filing Date 03.12.2019
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
CPC
A61K 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C12N 5/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
10Cells modified by introduction of foreign genetic material ; Not used, see subgroups
Applicants
  • 上海开拓者生物医药有限公司 SHANGHAI PHARMAEXPLORER CO., LTD. [CN]/[CN]
  • 钜川生物医药 PHARMAEXPLORER LIMITED
Inventors
  • 刘礼乐 LIU, Lile
  • 杨达志 YANG, Tatchi Teddy
  • 可汗S KHAN, Shireen
  • 段清 DUAN, Qing
  • 高婧 GAO, Jing
  • 姚婧妘 YAO, Jingyun
  • 许志强 XU, Zhiqiang
  • 孟亚丽 MENG, Yali
  • 王亮 WANG, Liang
  • 潘明明 PAN, Mingming
  • 周文明 ZHOU, Wenming
  • 夏珂 XIA, Ke
  • 郭翠翠 GUO, Cuicui
  • 童国珍 TONG, Guozhen
  • 王璐 WANG, Lu
  • 赵加洵 ZHAO, Jiaxun
  • 王冬旭 WANG, Dongxu
  • 戴朝晖 DAI, Chaohui
  • 王梦莹 WANG, Mengying
Agents
  • 上海一平知识产权代理有限公司 XU & PARTNERS, LLC.
Priority Data
201811467637.603.12.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CD47 ANTIBODY, PREPARATION METHOD THEREFOR AND USES THEREOF
(FR) ANTICORPS CD47, SON PROCÉDÉ DE PRÉPARATION ET SES APPLICATIONS
(ZH) CD47抗体及其制备方法和应用
Abstract
(EN)
An antibody targeting CD47, a preparation method therefor and uses thereof. A novel mouse or human-mouse chimeric antibody targeting CD47. A method for preparing the monoclonal antibody. The monoclonal antibody of the present invention may bind to a CD47 antigen with high specificity, has high affinity and significant activities, such as anti-tumor activity.
(FR)
Anticorps ciblant CD47, son procédé de préparation et ses applications. Nouvel anticorps chimérique souris ou souris/homme ciblant CD47. Procédé de préparation dudit anticorps monoclonal. Ledit anticorps monoclonal peut se fixer à un antigène CD47 à forte spécificité, présente une forte affinité et des activités remarquables, notamment une activité anti-tumorale.
(ZH)
一种靶向CD47的抗体、其制备方法和用途。一种新的靶向CD47的鼠源或人鼠嵌合抗体。制备该单克隆抗体的方法。该单克隆抗体能够高特异性地结合CD47抗原,具有很高的亲和力并且具有显著抗肿瘤等活性。
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