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1. WO2020114388 - SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUND, COMPOSITION CONTAINING THE SAME AND USE THEREOF

Publication Number WO/2020/114388
Publication Date 11.06.2020
International Application No. PCT/CN2019/122674
International Filing Date 03.12.2019
IPC
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/437 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 深圳市塔吉瑞生物医药有限公司 SHENZHEN TARGETRX, INC. [CN]/[CN]
Inventors
  • 王义汉 WANG, Yihan
  • 任兴业 REN, Xingye
Priority Data
201811488548.X06.12.2018CN
201811527134.313.12.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUND, COMPOSITION CONTAINING THE SAME AND USE THEREOF
(FR) COMPOSÉ PYRAZOLO[1,5-A]PYRIDINE SUBSTITUÉ, COMPOSITION LE CONTENANT ET UTILISATION ASSOCIÉE
(ZH) 取代的吡唑并[1,5-a]吡啶化合物及包含该化合物的组合物及其用途
Abstract
(EN)
The present disclosure provides a substituted pyrazolo[1,5-a]pyridine compound, composition containing same and use thereof. The substituted pyrazolo[1,5-a]pyridine compound is a compound represented by formula (I) or a tautomer, stereoisomer, prodrug, crystalline form, pharmaceutically acceptable salt, hydrate, or solvate thereof. The compound of the present invention and composition thereof are useful for treating RET kinase-mediated diseases or conditions and have more excellent pharmacokinetic properties.
(FR)
La présente invention concerne un composé pyrazolo[1,5-a]pyridine substitué, une composition le contenant et une utilisation associée. Le composé pyrazolo[1,5-a]pyridine substitué est un composé représenté par la formule (I) ou un tautomère, un stéréoisomère, un promédicament, une forme cristalline, un sel, un hydrate ou un solvate pharmaceutiquement acceptable de celui-ci. Le composé selon la présente invention et la composition de celui-ci sont utiles pour traiter des maladies ou des affections à médiation par la kinase RET et ont d'excellentes propriétés pharmacocinétiques.
(ZH)
本发明提供了一种取代的吡唑并[1,5-a]吡啶化合物及包含该化合物的组合物及其用途,所述的取代的吡唑并[1,5-a]吡啶化合物如式(I)所示化合物或其互变异构体、立体异构体、前药、晶型、药学上可接受的盐、水合物或溶剂合物。本发明化合物及其组合物可用于治疗RET激酶介导的疾病或病症且具有更优良的药代动力学性质。
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