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1. WO2020113933 - CONCENTRATE GROWTH FACTOR SLOW RELEASE FREEZE-DRIED MEMBRANE AND PREPARATION METHOD THEREFOR

Publication Number WO/2020/113933
Publication Date 11.06.2020
International Application No. PCT/CN2019/091155
International Filing Date 13.06.2019
IPC
A61K 9/70 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
70Web, sheet or filament bases
A61K 47/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 38/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
A61P 19/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
CPC
A61K 38/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
A61K 47/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 9/7007
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
70Web, sheet or filament bases ; ; Films; Fibres of the matrix type containing drug;
7007Drug-containing films, membranes or sheets
A61P 19/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
Applicants
  • 王丽萍 WANG, Liping [CN]/[CN]
Inventors
  • 王丽萍 WANG, Liping
  • 肖殷 XIAO, Yin
  • 万绵佳 WAN, Mianjia
  • 李正茂 LI, Zhengmao
  • 杜志斌 DU, Zhibin
  • 宿玉成 SU, Yucheng
  • 葛林虎 GE, Linhu
Agents
  • 广州华进联合专利商标代理有限公司 ADVANCE CHINA IP LAW OFFICE
Priority Data
201811463195.803.12.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CONCENTRATE GROWTH FACTOR SLOW RELEASE FREEZE-DRIED MEMBRANE AND PREPARATION METHOD THEREFOR
(FR) MEMBRANE LYOPHILISÉE À LIBÉRATION LENTE DE FACTEUR DE CROISSANCE CONCENTRÉ ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 浓缩生长因子缓释冻干膜及其制备方法
Abstract
(EN)
A concentrate growth factor slow release freeze-dried membrane and a preparation method therefor. The preparation method comprises the following steps: providing concentrate growth factors; dispersing the concentrate growth factors in an aqueous solution of sodium alginate to obtain a mixed solution; dropwise adding the mixed solution to an aqueous solution containing divalent metal cations while stirring so as to enable the sodium alginate to clad the concentrate growth factors and obtain composite microspheres of the concentrate growth factors and the sodium alginate; and dispersing the composite microspheres in an aqueous solution of chitosan, and performing freeze drying so as to obtain the concentrate growth factor slow release freeze-dried membrane. The concentrate growth factor slow release freeze-dried membrane prepared by the method has the advantages that the release rate of the concentrate growth factors is controllable, the mechanical property is good, and the membrane can be stored for a long term.
(FR)
La présente invention concerne une membrane lyophilisée à libération lente de facteur de croissance concentré et son procédé de préparation. Le procédé de préparation comprend les étapes suivantes : fourniture de facteurs de croissance concentrés ; dispersion des facteurs de croissance concentrés dans une solution aqueuse d’alginate de sodium pour obtenir une solution mixte ; ajout goutte à goutte de la solution mixte à une solution aqueuse contenant des cations métalliques divalents tout en agitant afin de permettre à l’alginate de sodium de plaquer les facteurs de croissance concentrés et d'obtenir les microsphères composites des facteurs de croissance concentrés et l’alginate de sodium ; et disperser les microsphères composites dans une solution aqueuse de chitosane, et effectuer la lyophilisation afin d’obtenir la membrane lyophilisée à libération lente de facteur de croissance concentré. La membrane lyophilisée à libération lente de facteur de croissance concentré préparée selon le procédé présente les avantages que la vitesse de libération des facteurs de croissance concentrés peut être régulée, la propriété mécanique est bonne, et la membrane peut être stockée à long terme.
(ZH)
一种浓缩生长因子缓释冻干膜及其制备方法,包括以下步骤:提供浓缩生长因子;将浓缩生长因子分散在海藻酸钠的水溶液中,得到混合溶液;边搅拌边向含有二价金属阳离子的水溶液中滴加混合溶液,以使海藻酸钠包覆浓缩生长因子,得到浓缩生长因子和海藻酸钠的复合微球;将复合微球分散在壳聚糖的水溶液中,冷冻干燥,得到浓缩生长因子缓释冻干膜。上述方法制备的浓缩生长因子缓释冻干膜,具有浓缩生长因子释放速率可控,机械性能较好且能长期储存等优点。
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