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1. WO2020113237 - NEXT-GENERATION MOLECULAR PROFILING

Publication Number WO/2020/113237
Publication Date 04.06.2020
International Application No. PCT/US2019/064078
International Filing Date 02.12.2019
IPC
G06N 20/00 2019.01
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
NCOMPUTER SYSTEMS BASED ON SPECIFIC COMPUTATIONAL MODELS
20Machine learning
A61B 5/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
G06N 5/02 2006.01
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
NCOMPUTER SYSTEMS BASED ON SPECIFIC COMPUTATIONAL MODELS
5Computer systems using knowledge-based models
02Knowledge representation
G16H 10/40 2018.01
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
10ICT specially adapted for the handling or processing of patient-related medical or healthcare data
40for data related to laboratory analysis, e.g. patient specimen analysis
G16H 10/60 2018.01
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
10ICT specially adapted for the handling or processing of patient-related medical or healthcare data
60for patient-specific data, e.g. for electronic patient records
G16H 20/70 2018.01
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
20ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
70relating to mental therapies, e.g. psychological therapy or autogenous training
CPC
A61B 5/4836
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
48Other medical applications
4836Diagnosis combined with treatment in closed-loop systems or methods
A61B 5/7267
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
72Signal processing specially adapted for physiological signals or for diagnostic purposes
7235Details of waveform analysis
7264Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
7267involving training the classification device
G06N 20/00
GPHYSICS
06COMPUTING; CALCULATING; COUNTING
NCOMPUTER SYSTEMS BASED ON SPECIFIC COMPUTATIONAL MODELS
20Machine learning
G06N 5/02
GPHYSICS
06COMPUTING; CALCULATING; COUNTING
NCOMPUTER SYSTEMS BASED ON SPECIFIC COMPUTATIONAL MODELS
5Computer systems using knowledge-based models
02Knowledge representation
G16H 10/40
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
10ICT specially adapted for the handling or processing of patient-related medical or healthcare data
40for data related to laboratory analysis, e.g. patient specimen analysis
G16H 10/60
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
10ICT specially adapted for the handling or processing of patient-related medical or healthcare data
60for patient-specific data, e.g. for electronic patient records
Applicants
  • CARIS MPI, INC. [US]/[US]
Inventors
  • ABRAHAM, Jim
  • SPETZLER, David
  • HELMSTETTER, Anthony
  • KORN, Wolfgang Michael
  • MAGEE, Daniel
Agents
  • DEYOUNG, Janice Kugler
  • DARNO, Patrick A.
  • REYNOLDS, Kimberly A.
Priority Data
62/774,08230.11.2018US
62/788,68904.01.2019US
62/789,49507.01.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NEXT-GENERATION MOLECULAR PROFILING
(FR) PROFILAGE MOLÉCULAIRE DE NOUVELLE GÉNÉRATION
Abstract
(EN)
Comprehensive molecular profiling provides a wealth of data concerning the molecular status of patient samples. Such data can be compared to patient response to treatments to identify biomarker signatures that predict response or non-response to such treatments. This approach has been applied to identify biomarker signatures that strongly correlate with response of colorectal cancer patients to FOLFOX. Described herein are data structures, data processing, and machine learning models to predict effectiveness of a treatment for a disease or disorder of a subject having a particular set of biomarkers, as well as an exemplary application of such a model to precision medicine, e.g., to methods for selecting a treatment based on a molecular profile, e.g., a treatment comprising administration of 5-fluorouracil/leucovorin combined with oxaliplatin (FOLFOX) or with irinotecan (FOLFIRI).
(FR)
Le profilage moléculaire complet fournit une richesse de données concernant l'état moléculaire d'échantillons de patient. De telles données peuvent être comparées à une réponse de patient à des traitements pour identifier des signatures de biomarqueurs qui prédisent une réponse ou une non-réponse à de tels traitements. Cette approche a été appliquée pour identifier des signatures de biomarqueurs qui sont fortement corrélées à la réponse des patients atteints d'un cancer colorectal au FOLFOX. L'invention concerne des structures de données, un traitement de données et des modèles d'apprentissage machine pour prédire l'efficacité d'un traitement pour une maladie ou un trouble d'un sujet ayant un ensemble particulier de biomarqueurs, ainsi qu'un exemple d'application d'un tel modèle à un médicament de précision, par exemple, des procédés de sélection d'un traitement sur la base d'un profil moléculaire, par exemple, un traitement comprenant l'administration de 5-fluorouracile/leucovorine combinée à l'oxaliplatine (FOLFOX) ou à l'irinotécan (FOLFIRI).
Latest bibliographic data on file with the International Bureau