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1. WO2020113210 - FUNCTIONAL SCREEN FOR SMALL MOLECULE AND MONOCLONAL ANTIBODY DRUG SENSITIVITY IN MULTIPLE MYELOMA PATIENTS

Publication Number WO/2020/113210
Publication Date 04.06.2020
International Application No. PCT/US2019/063977
International Filing Date 02.12.2019
IPC
C12N 5/077 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
077Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
C12N 5/078 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
G01N 33/50 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
CPC
G01N 2333/70589
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
705Assays involving receptors, cell surface antigens or cell surface determinants
70589CD45
G01N 2333/70596
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
705Assays involving receptors, cell surface antigens or cell surface determinants
70596Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
G01N 33/5011
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
5005involving human or animal cells
5008for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
5011for testing antineoplastic activity
Applicants
  • THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE [US]/[US]
Inventors
  • SHERBENOU, Daniel
  • WALKER, Zachary
  • VANWYNGARDEN, Michael
Agents
  • WIWCHAR, Michael
  • WALKER, Dave
  • WOMACK, Lane
Priority Data
62/774,17701.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FUNCTIONAL SCREEN FOR SMALL MOLECULE AND MONOCLONAL ANTIBODY DRUG SENSITIVITY IN MULTIPLE MYELOMA PATIENTS
(FR) ÉCRAN FONCTIONNEL POUR PETITE MOLÉCULE ET SENSIBILITÉ À UN MÉDICAMENT À BASE D'ANTICORPS MONOCLONAUX CHEZ DES PATIENTS ATTEINTS DE MYÉLOME MULTIPLE
Abstract
(EN)
An ex vivo method of determining sensitivity of multiple myeloma cells obtained from a multiple myeloma patient to chemotherapeutic agents, and methods of specifically treating the patient with chemotherapeutic agents to which the multiple myeloma cells are sensitive.
(FR)
L'invention concerne un procédé ex vivo de détermination de la sensibilité de cellules de myélome multiple obtenues auprès d'un patient atteint de myélome multiple à des agents chimiothérapeutiques, et des procédés de traitement spécifique du patient avec des agents chimiothérapeutiques auxquels les cellules de myélome multiple sont sensibles.
Latest bibliographic data on file with the International Bureau