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1. WO2020113188 - METHODS FOR DOSING AND TREATMENT OF B CELL MALIGNANCIES IN ADOPTIVE CELL THERAPY

Publication Number WO/2020/113188
Publication Date 04.06.2020
International Application No. PCT/US2019/063883
International Filing Date 29.11.2019
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 35/17 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61K 39/001112
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0005Vertebrate antigens
0011Cancer antigens
001102Receptors, cell surface antigens or cell surface determinants
001111Immunoglobulin superfamily
001112CD19, B4
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • JUNO THERAPEUTICS, INC. [US]/[US]
Inventors
  • GILLENWATER, Heidi
Agents
  • AHN, Sejin
  • POTTER, Karen
Priority Data
62/774,16830.11.2018US
62/774,85803.12.2018US
62/847,89714.05.2019US
62/854,95730.05.2019US
62/931,14305.11.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR DOSING AND TREATMENT OF B CELL MALIGNANCIES IN ADOPTIVE CELL THERAPY
(FR) MÉTHODES DE DOSAGE ET DE TRAITEMENT DE MALIGNITÉS DE LYMPHOCYTES B AU MOYEN D'UNE THÉRAPIE CELLULAIRE ADOPTIVE
Abstract
(EN)
Provided are adoptive cell therapy methods involving the administration of doses of cells for treating disease and conditions, including certain B cell malignancies. The cells generally express recombinant receptors such as chimeric antigen receptors (CARs). In some embodiments, the methods are for treating subjects with chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). In some embodiments, the methods are for treating subjects with relapsed or refractory CLL and SLL. Also provided are articles of manufacture and prophylactic treatments in connection with adoptive therapy methods.
(FR)
L'invention concerne des méthodes de thérapie cellulaire adoptive impliquant l'administration de doses de cellules pour le traitement de maladies et de pathologies, y compris certaines malignités des lymphocytes B. Les cellules expriment généralement des récepteurs recombinants tels que des récepteurs antigéniques chimériques (CAR). Dans certains modes de réalisation, les méthodes sont destinées au traitement de sujets souffrant d'une leucémie lymphoïde chronique (LLC) d'un lymphocytome (SLL). Dans certains modes de réalisation, les méthodes sont destinées au traitement de sujets atteints de CLL et de SLL réfractaire ou de type récidive. L'invention concerne également des articles manufacturés et des traitements prophylactiques en relation avec des méthodes de thérapie adoptive.
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