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1. WO2020113182 - EXPANSION OF NATURAL KILLER CELLS AND ILC3 CELLS WITH NOVEL AROMATIC COMPOUNDS

Publication Number WO/2020/113182
Publication Date 04.06.2020
International Application No. PCT/US2019/063876
International Filing Date 29.11.2019
IPC
C12N 5/0783 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
CPC
C12N 2501/145
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
10Growth factors
145Thrombopoietin [TPO]
C12N 2501/2315
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
20Cytokines; Chemokines
23Interleukins [IL]
2315Interleukin-15 (IL-15)
C12N 5/0646
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
06Animal cells or tissues; Human cells or tissues
0602Vertebrate cells
0634Cells from the blood or the immune system
0646Natural killers cells [NK], NKT cells
Applicants
  • CELULARITY, INC. [US]/[US]
Inventors
  • HARIRI, Robert J.
  • ZHANG, Xiaokui
  • KANG, Lin
  • VAN DER TOUW, William
  • VOSKINARIAN-BERSE, Vanessa
  • XUAN, Guo
Agents
  • KNUDSEN, Geoffry T.
Priority Data
62/774,11430.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) EXPANSION OF NATURAL KILLER CELLS AND ILC3 CELLS WITH NOVEL AROMATIC COMPOUNDS
(FR) MULTIPLICATION DE CELLULES TUEUSES NATURELLES ET DE CELLULES ILC3 AVEC DE NOUVEAUX COMPOSÉS AROMATIQUES
Abstract
(EN)
Provided herein are methods of producing natural killer (NK) cells and/or ILC3 cells using a three-stage expansion and differentiation method with media comprising stem cell mobilizing factors. Also provided herein are methods of suppressing tumor cell proliferation using the NK cells and/or ILC3 cells and the NK cell and/or ILC3 cell populations produced by the three-stage methods described herein, as well as methods of treating individuals having cancer or a viral infection, comprising administering the NK cells and/or ILC3 cells and the NK cell and/or ILC3 cell populations produced by the three-stage methods described herein to an individual having the cancer or viral infection.
(FR)
La présente invention concerne des procédés de production de cellules tueuses naturelles (NK) et/ou de cellules ILC3 à l'aide d'un procédé de multiplication et de différenciation en trois étapes en utilisant des milieux comprenant des facteurs de mobilisation de cellules souches. L'invention porte en outre sur des procédés pour stopper la prolifération de cellules tumorales à l'aide des cellules NK et/ou des cellules ILC3 et des populations de cellules NK et/ou des cellules ILC3 produites par les procédés en trois étapes tels que décrits dans la description, ainsi que des méthodes de traitement de sujets atteints de cancer ou d'une infection virale, comprenant l'administration des cellules NK et/ou des cellules ILC3 et des populations de cellules NK et/ou des cellules ILC3 produites par les procédés en trois étapes tels que décrits dans la description, à un sujet atteint de cancer ou d'une infection virale.
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