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1. WO2020113124 - METHODS, COMPOSITIONS, AND KITS FOR TREATING OCULAR DISEASES

Publication Number WO/2020/113124
Publication Date 04.06.2020
International Application No. PCT/US2019/063781
International Filing Date 27.11.2019
IPC
A61K 31/7036 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034attached to a carbocyclic compound, e.g. phloridzin
7036having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07H 15/236 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
20Carbocyclic rings
22Cyclohexane rings, substituted by nitrogen atoms
222Cyclohexane rings, substituted by at least two nitrogen atoms
226with at least two saccharide radicals directly attached to the cyclohexane rings
234attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
236a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamicin
CPC
A61K 31/7036
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034attached to a carbocyclic compound, e.g. phloridzin
7036having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • ELOXX PHARMACEUTICALS [US]/[US]
Inventors
  • VAN DUZER, John
  • WILLIAMS, Greg
Agents
  • MORRIS, Pat
  • GALLAGHER, Audrey
Priority Data
62/773,13129.11.2018US
62/783,85221.12.2018US
62/838,90525.04.2019US
62/878,26024.07.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS, COMPOSITIONS, AND KITS FOR TREATING OCULAR DISEASES
(FR) MÉTHODES, COMPOSITIONS ET KITS PERMETTANT DE TRAITER DES MALADIES OCULAIRES
Abstract
(EN)
Provided herein are methods of treating an ocular disease associated with one or more nonsense mutation in a subject using one or more aminoglycosides and/or derivatives thereof. The pharmaceutical compositions and kits containing one or more aminoglycosides and/or derivatives thereof for treating the ocular disease are disclosed.
(FR)
L'invention concerne des méthodes de traitement d'une maladie oculaire associée à une ou plusieurs mutations non-sens chez un sujet à l'aide d'un ou de plusieurs aminoglycosides et/ou de dérivés de ces derniers. L'invention concerne également des compositions pharmaceutiques et des kits contenant un ou plusieurs aminoglycosides et/ou des dérivés de ces derniers afin de traiter la maladie oculaire.
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