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1. WO2020113099 - METHOD FOR TREATING OR PREVENTING SEIZURES ASSOCIATED WITH AN EPILEPTIC DISORDER

Publication Number WO/2020/113099
Publication Date 04.06.2020
International Application No. PCT/US2019/063748
International Filing Date 27.11.2019
IPC
A61K 31/4468 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
4468having a nitrogen atom directly attached in position 4, e.g. clebopride, fentanyl
A61K 31/5513 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
551having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
55131,4-Benzodiazepines, e.g. diazepam
A61P 25/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
CPC
A61K 31/5513
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
551having two nitrogen atoms, e.g. dilazep
55131,4-Benzodiazepines, e.g. diazepam ; or clozapine
A61K 9/0019
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
A61P 25/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
Applicants
  • HOWARD, Gary Aaron [US]/[US]
  • ZUCCO SASSI YONEZAWA SIVIGLIA, Debora [FR]/[FR]
Inventors
  • HOWARD, Gary Aaron
  • ZUCCO SASSI YONEZAWA SIVIGLIA, Debora
Agents
  • YANG, Charles C.
Priority Data
62/772,81129.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR TREATING OR PREVENTING SEIZURES ASSOCIATED WITH AN EPILEPTIC DISORDER
(FR) PROCÉDÉ DE TRAITEMENT OU DE PRÉVENTION DE CRISES ASSOCIÉES À UN TROUBLE ÉPILEPTIQUE
Abstract
(EN)
The present inventive concept is related to and describes a method for treating the neurovascular disruption underlying neurological and nervous system bioelectrical dysregulation associated with epilepsy, neuropathic pain, neurodegenerative disorders, and seizures by improving the neurophysiological environment and then enabling by sustained sedation a biomechanism of glial cells for neuronal repairs.
(FR)
Le présent concept de l’invention concerne et décrit un procédé de traitement d'une perturbation neurovasculaire sous-jacente à une dérégulation bioélectrique du système neurologique et nerveux associée à l’épilepsie, à la douleur neuropathique, aux troubles neurodégénératifs, et aux crises d’épilepsie par amélioration de l’environnement neurophysiologique et ensuite en permettant la sédation prolongée d’un biomécanisme des cellules gliales pour les réparations neuronales.
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